实现艾滋病功能性治愈的策略

Developing strategies to achieve functional cure of AIDS

高效抗反转录病毒治疗(HAART)使艾滋病的发病率和死亡率显著降低,但是HAART对艾滋病病毒(HIV)潜伏池的清除效果并不理想。探索激活和清除HIV潜伏池的方法以期获得临床功能性治愈,是当前艾滋病研究的热点。正在进行研究及实践的方法有:(1)增强抗反转录病毒治疗;(2)感染早期治疗;(3)激化潜伏HIV,清除病毒潜伏池;(4)治疗性疫苗;(5)基因治疗。

Highly active antiretroviral therapy（HAART）has led to a major reduction in HIV-related mortality and morbidity,however,HAART cannot cure HIV patients because it＇s poor efficacy on eradicating HIV latent reservoir.Developing strategies to achieve functional cure of AIDS includes：（1）streghten HAART;（2）early HIV treatment;（3）activate latent HIV,clear latent reservoir;（4）therapeutic vaccine;（5）gene therapy.