466例药品不良反应报告分析

Adverse Drug Reaction: Analysis of 466 Cases

目的:了解深圳市福田区慢性病防治院(以下简称"我院")药品不良反应(ADR)发生的特点和规律,促进临床合理用药。方法:采用回顾性调查研究方法,对我院2013年收集到的466例ADR报告进行统计分析。结果:466例发生ADR的患者中,男性206例(占44.21%),女性260例(占55.79%);年龄2 d^90岁,<20岁的患者166例,20~<40岁的患者81例,40~<60岁的患者102例,≥60岁的患者117例;引发ADR的给药途径以静脉给药为主,为451例(占96.78%);引起的ADR的药物以抗病原微生物药为主(244例,占52.36%);ADR的临床表现以皮肤及其附件损害为主(165例,占35.41%)。结论:ADR的发生与药品的性质、患者的个体差异、临床应用途径等多种因素相关,临床应严格掌握用药指征,加强ADR监测工作,促进合理用药。

OBJECTIVE： To analyze the characteristics and the regular pattern of the occurrence of adverse drug reactions（ ADR） in Shenzhen Futian District Chronic Disease Hospital（ hereinafter referred to as ＂our hospital＂） so as to promote clinical rational use of drug. METHODS： By retrospective survey,a statistical analysis was performed on466 cases of ADR reports collected in our hospital in 2013. RESULTS： Of the total 466 ADR cases,206（ 44. 21%）were male versus 260（ 55. 79%） female; the patients aged from 2 days to 90 years,with 166 aged 〈20 years,81 aged from 20 to 〈40 years,102 from 40 to〈 60 years and 117 aged ≥60 years; 451（ 96. 78%） were induced by intravenous administration,and 244 cases（ 52. 36%） were induced by antimicrobial drugs; the ADR appeared manily as lesions of skin and its appendants（ 165 cases,accounting for 35. 41%）. CONCLUSIONS： ADR is associated with a variety of factors including drug property,individual differences and route of administration etc. It is important to follow indications in drug use and strengthen ADR monitoring to promote raitonal use of drug.