摘要
乙酰肝素酶（hepranase,HPSE）是哺乳动物细胞中唯一能切割细胞外基质中硫酸乙酰肝素蛋白多糖侧链-硫酸乙酰肝素（heparan sulfate,HS）的一种葡萄糖醛酸内切酶.HPSE为单拷贝基因,可促进肿瘤转移和浸润、血管生成,维持晶状体囊膜结构,促进凝血活性以及参与胚胎组织发育等.关于HPSE与眼科疾病的关系报道较少,目前研究发现其与角膜炎症、新生血管形成,晶状体疾病、视网膜生理结构及新生血管形成以及视网膜色素上皮细胞增生、迁移等方面有关.
Heparanase （HPSE） in the endo-D-glucuronidase is the only mammalian heparin sulfate （HS）-degrading enzymes,which cleaves heparan sulfate （HS） that links to heparin sulfate proteoglycans.HPSE is a single copy gene,which can promotes tumor invasion and metastasis,angiogenesis,maintaining lens membrane structure,coagulation function,embryonic tissue development and other aspects of participation.Reports about the relationship between HPSE and ophthalmology diseases is less.The present studies found that HPSE was associated with the corneal inflammation and neovascularization,lens diseases,physiological structure and neovascularization of retina,proliferation and migration of retinal pigmeng epithelium cells.
出处
《国际眼科纵览》
2015年第1期30-33,共4页
International Review of Ophthalmology
基金
云南省科技厅应用基础面上项目（2011FB062）
