Coats病的发病机制及治疗

Pathogenesis and treatment of Coats disease

Coats病是一种儿童多见的眼底病,典型临床表现是视网膜毛细血管扩张伴视网膜层间及视网膜下的渗出.本病发病机制不明确,受累眼视力预后不佳,严重的患者可因并发症导致眼球摘除.目前认为其发病机制与血管因素、基因及细胞因子相关.其治疗方法包括激光、冷冻及药物治疗,多采取联合治疗.玻璃体手术治疗作为复杂病例可选择的方法,但应慎重.

Coats disease is mostly unilateral and affects mainly males during childhood.It characterizes by retinal telangiectasis,intraretinal and subretinal exudation.The pathogenesis of Coats dieases is still unclear.The affected eye usually has poor prognosis,and enucleation may be considered in some of severe patients.In current,the pathogenesis is considered related to the vascular factors,genes,and cytokines.The treatments of Coats disease include laser,cryotherapy,and medications,and the combined therapy is the commom choice.The vitrectomy can be choose for the refractory cases,while the surgery should be carefully choosed.