原发性高血压患者血浆同型半胱氨酸的分布特征

Distribution and characteristic of plasma homocysteine in patients with essential hypertension

目的分析不同性别、年龄的原发性高血压患者血浆同型半胱氨酸的水平和分布特征。方法收集本院门诊收治的原发性高血压患者2509例作为研究对象,对血浆同型半胱氨酸的分布特征和H型高血压患病率进行统计学分析。结果 1样本的几何均数为14.1μmol/L,男性几何均数为15.6μmol/L,女性为12.8μmol/L,二者差异具有显著性(P<0.05);2以年龄分层,男性血浆同型半胱氨酸水平亦高于女性,差异均具有显著性(P<0.05);3 H型高血压占所有高血压患者的88.0%,男性H型高血压患病率为93.2%,高于女性(82.8%),是女性的1.13倍;4以年龄分层,男性H型高血压患病率均高于女性,差异具有显著性(P<0.05)。结论原发性高血压患者血浆同型半胱氨酸水平呈偏态分布,存在年龄、性别差异,男性H型高血压患病率高于女性。

Objective To study the serum homocysteine distribution, characteristics and levels in diffrent sex and age groups with essential hypertension. Method The subjects under study was 2509 cases of essential hypertensive patients from our hospital outpatient, plasma homocysteine distribution and prevalence of H-type hypertensive were statistically analyzed. Result ① Geometric mean of serum Hcy was 14.1μmol/L in the study pupulation, 15.6μmol/L in males and 12.8μmol/L in females （P〈0.05）;②Plasma homocysteine level of per age in the males was also higher than females （P〈0.05）;③H-type hypertension accounted for 88.0%in the study population, the prevalence rate of H-type hypertension was 93.2%in males, the males had 1.13 times higher prevalence rate than the females （82.8%）;④The prevalence rate of H-type hypertension of per age in the males was also higher than females （P〈0.05）. Conclusion Plasma homocysteine level with essential hypertension population is signiifcantly different by sex and age, the prevalence rate of H-type hypertension in the males is higher than females.