新制鲤鱼汤佐治肾病综合征低蛋白性水肿疗效观察

Clinical study on the effect of new carp soup in treating low protein edema of nephrotic syndrome

目的观察新制鲤鱼汤治疗小儿肾病综合征低蛋白性水肿的临床疗效。方法 60例肾病综合征低蛋白性水肿患儿随机分为2组,每组30例。在西医常规治疗的基础上,对照组给予人血白蛋白和呋塞米静脉滴注,治疗组给予新制鲤鱼汤口服,4周后统计2组的临床疗效,并对水肿消退、尿蛋白转阴患儿6月后随访水肿复发情况。结果治疗组显愈率73.3%,优于对照组的57.2%,2组比较差异有统计意义(P<0.05);2组西医主症积分、中医主症积分较治疗前均减少(P<0.05),说明2组治疗均有效;治疗后2组间在水肿、低蛋白血症、蛋白尿、血尿、倦怠乏力、脘腹胀满方面比较,差异有统计意义(P<0.05),提示治疗组优于对照组;2组患儿随访6月,治疗组复发率6.67%,明显低于对照组的20.0%。结论新制鲤鱼汤治疗小儿肾病综合征低蛋白性水肿,在消除水肿、提升白蛋白水平、减轻蛋白尿、血尿、水肿复发方面疗效显著,且安全价廉。

Objective To observe the effect of new carp soup in treating low protein edema of infantile nephrotic syndrome. Methods 60 cases of nephrotic syndrome with low protein edema were randomly divided into 2 groups,30 cases in each group. On the basis of routine treatment,the control group was given serum albumin and furosemide,the treatment group was given new carp soup. After 4 weeks of treatment,the effect of the 2 groups was analyzed and six months after the treatment,the patients were followed up about edema and urine protein. Results The curative rate was 73.3% in treatment group significantly better than 56.2% in control group,and the difference was statistically significant（ P〈0. 05）; the main symptom score,TCM syndrome score decreased in the 2 groups（ P〈0.05）; treatment group was better than control group in edema,hypoproteinemia,proteinuria,hematuria,fatigue,abdominal distension（ P〈0. 05）; after six months follow up,the recurrence rate was 6. 67% in the treatment group significantly lower than 20. 0% in the control group. Conclusion New carp soup can get good effect in treating low protein edema of nephrotic syndrome in eliminating edema,promoting albumin levels,reducing recurrence of proteinuria,hematuria,edema,which is safe with low cost.