钙磷脂结合蛋白Ⅱ在食管鳞癌组织中的表达及临床意义

The expression and clinical significance of AnnexinⅡ in esophageal squamous cell cancer

目的研究钙磷脂结合蛋白Ⅱ(AnnexinⅡ)在食管鳞癌及癌旁组织中的表达,分析其与食管鳞癌临床病理特征间的关系。方法应用免疫组化法检测AnnexinⅡ在41例食管鳞癌组织及配对的癌旁组织、10例正常胃组织中的表达。结果 AnnexinⅡ蛋白在食管鳞癌组织中的表达明显高于癌旁组织及正常组织,差异具有统计学意义(P<0.05)。食管鳞癌组织中AnnexinⅡ的表达水平与肿瘤分化程度及淋巴结是否转移相关(P<0.05),而与年龄、性别、浸润深度、临床分期无关(均P>0.05)。结论AnnexinⅡ的表达在食管鳞癌的发生、发展过程中起重要作用,有望作为食管鳞癌诊治的新靶点。

Objective To expcore the expression and clinical significance of AnnexinⅡin esophageal squamous cell cancer and analyze the relationship between AnnexinⅡand clinicopathological features. Methods Im-munohistochemistry was used to detect the expression of AnnexinⅡamong 41 matched pairs of esophageal squamous cell cancer tissues and 10 cases of normal esophageal tissues. Results There were obviously differences in the expression of AnnexinⅡin esophageal squamous cell cancer tissues, circa-cancerous tissues and normal esophageal tissues（P〈0. 05）. In the specimens of esophageal squamous cell cancer, expression of AnnexinⅡrelated to cell differentiation of tumors and metastasis of lymph node, no relation to age, sex, depth of invasion and clinical stage（P〉0. 05）. Conclusions The expressions of AnnexinⅡhad important effect in development and growth in esophageal squamous cell cancer, and might become a diagnosis index and treating target in clinic treatment.