两种术前放疗方案在直肠癌综合治疗中的应用分析

Analysis of two preoperative radiotherapy regimens in multimodality therapy of rectal carcinoma

目的探讨术前大分割短程放疗与常规分割长程放疗对直肠癌根治术患者的临床疗效和不良反应。方法将2010年9月至2013年9月收治的cT2-3N0-2M0直肠癌患者随机分成短程组和长程组。短程组给予大分割短程放疗,7-8周后行直肠癌根治术;长程组给予常规分割长程放疗,4-6周后行直肠癌根治术。比较两组患者完全病理学应答率、围手术期不良反应。结果短程组和长程组术后完全病理学应答率为15.1%与15.6%,P〉0.05。两组患者切口感染、腹腔内感染、出血、吻合口瘘、切口不愈合发生率、术后1年复发率和死亡率相近。结论两组患者具有相似的完全病理学应答率、围手术期不良反应发生率、术后1年复发率和死亡率。

Objective To investigate the clinical effect and adverse reaction of preoperative short-course and long-course radiotherapy in radical operation of rectal carcinoma. Methods Some patients staged as cT2-3 N0-2 M0 were randomly arranged into two group,short-course group received radiotherapy and surgery after 7-8 weeks,long-course group received radiotherapy and surgery after 4-6 weeks. Results The rate complete pathological of response was 15. 1% for patients who received short-course radiotherapy and 15. 6% for patients who had long-course radiotherapy. There were no significant differences between two groups and there were similar wound infection, intra-abdominal infection, haemorrhage, anastomotic leak, wound dehiscence, mortality and recurrence rate 1 year after surgery in two groups. Conclusions The rate complete pathological of response, adverse reaction, mortality and recurrence 1 year after surgery in two groups were similar.