养血清脑颗粒治疗后循环缺血的临床研究

Clinical research ofYangxue-Qingnao granules on posterior circulation of ischemia

目的：观察养血清脑颗粒治疗后循环缺血的临床疗效。方法收集2012年9月－2014年1月武汉大学人民医院神经内科门诊后循环缺血患者52例，采用简单化随机分组法分为2组各26例。对照组口服盐酸氟桂利秦胶胶囊、甲磺酸倍他司汀片治疗；治疗组在对照组治疗基础上加服养血清脑颗粒。观察患者治疗前后临床症状、经颅多普勒超声、颈部血管超声的变化。结果治疗后，治疗组总有效率为96.2%（25/26），对照组为76.9%（20/26），2组比较差异有统计学意义（χ2＝4.127，P＝0.042）。治疗后，2组椎动脉、基底动脉、小脑后下动脉经颅多普勒超声血流速度均较同组治疗前下降（治疗组t值分别为20.624、13.773、9.485，对照组分别为13.203、9.550、5.655，P均＜0.01），治疗组下降情况优于对照组（t值分别为5.410、5.151、3.837，P均＜0.01）。治疗组颈动脉内膜中膜厚度下降25例（96.2%）、未下降1例（3.8%）；对照组下降18例（69.2%）、未下降6例（23.1%），2组颈动脉内膜中膜厚度下降率比较，差异有统计学意义（χ2＝5.318，P＝0.021）。结论养血清脑颗粒可明显改善后循环缺血患者血流动力学及颈动脉内膜中膜厚度，短期疗效明显。

Objective To evaluate the curative effect and security ofYangxue-Qingnao granules on posterior circulation ischemia.Methods 52 patients with posterior circulation ischemia from September 2012 to January 2014 in Remin hospital of Wuhan Universityk, were randomly recruited into a control group and a treatment group, with 26 cases in each group. The control group was only treated with flunarizine HCL and Betahistine Mesilate Tablets, while the treatment group was givenYangxue-Qingnao granules based on the control group. The change of clinical symptoms, TCD and cervical vascular ultrasound were observed before and after the treatment.Results After the treatment, the total effective rate of treatment group was significantly different to the control group （96.2%vs. 76.9%;χ2=4.127,P=0.042）. The changes of blood flow velocity of vertebral artery, basilar artery and posterior inferior cerebellar artery were all decreased after the treatment in both groups （tvalue in the treatment group were 20.624, 13.773, and 9.485 respectively,t value in the control group were 13.203, 9.550, and 5.655, respectively, allP〈0.01）, besides such decreases in the treatment group were better than the control group （allP〈0.01）. After the treatment, the condition of carotid IMT decrease was significantly better in the treatment group than the control group （the number rate of IMT decrease was （96.2%vs. 69.2%;χ2=5.318,P=0.021）.ConclusionYangxue-Qingnao granules can obviously improve the blood flow velocity and the thickness of IMT in patients with posterior circulation ischemia. The short-term curative effect is obvious.