呼吸道病毒感染在婴幼儿喘息及支气管哮喘发病中的作用

Function of respiratory virus infection in infant＇s and children＇s wheezing and bronchial asthma attack

本文综述呼吸道病毒感染在婴幼儿毛细支气管炎、支气管哮喘（简称哮喘）等喘息性疾病中的作用,及病毒感染对哮喘和变态反应性疾病的影响.呼吸道病毒感染可以损伤气道上皮,直接激活末梢神经,导致气道细胞产生多种炎性细胞因子及趋化因子,导致喘息、咳嗽等临床症状的产生,同时影响机体免疫功能,导致免疫功能紊乱.呼吸道病毒感染对喘息及哮喘患儿的影响是急性损害和长期作用并存,特应性体质的患儿对病毒感染更加敏感.有效地控制婴幼儿时期的呼吸道病毒性感染,可以减少喘息性疾病的发作,并最终减少哮喘的发生.

This paper aims to summarize the function of respiratory virus infection in asthmatic diseases suffered by infants and children,such as capillary bronchitis and bronchial asthma （asthma）,and the effect of virus infection in asthma and allergic diseases.Respiratory virus infection will injure airway epithelium and activate peripheral nerve,leading air passage cells to produce various inflammatory cytokines and chemokines,and resulting in clinical symptoms of wheezing and coughing;meanwhile,it will affect the body immunity,leading to immune dysfunction.The effect of respiratory virus infection in infant and children patients suffering wheeze and asthma is characteristic of a combination of acute injury and long-term effect.Infant and children patients with habitus of atopy will be more sensitive to virus infection.Effectively controlling respiratory virus infections in infancy can reduce the possibility of asthmatic diseases attack,thus reducing the possibility of asthma attack.