基于自然药学观药物体系的中药药物本质相关性思考

On Chinese medicine essence based on drug system of natural pharmacy concept

基于自然药学观药物体系思维构架中药药物本质认识论,以提高对中药药物本质与有效物质基础的认识水平,指导中药理想药物体系及其药物研究。应用科学论、还原论、系统论、整体观进行中药药物体系基本特性表征关联分析。研究结果表明:药物体系自然性、协同性、亲和性三大基本特性表征出中药药物物质有机关联整合效应状态及其自然亲缘关系规律与亲缘药物学架构,体现中药及其复方药物本质与有效物质基础内涵。因此,基于药物体系思维构架中药药物本质认识论,可从微观系统认识中药药物本质与有效物质基础内涵,并可指导中药理想药物研究,预知与发现中药新的药物体系与新的中药原,从而为临床拓展丰富新的中药理想药物体系及其药物。

Based on the nature medicine concept drug system, the epistemology of drug essence in traditional Chinese medicine （TCM） was set up, to improve understanding the essence of TCM drugs, effective material base level, and guiding research on the optimum drug system and drugs of TCM. The theories of applied science, reductionism, system theory, and holistic view were used for basic characteristic analysis of the drug system in TCM. Three basic characteristics of drug system （naturalness, collaborative and compatibility） reflect the organic integration effect state, natural related laws, related pharmacology and the connotation of the effective material basic in single and compound drugs of TCM. The research based on drug system thinking and its basic properties characterization, can perceive the essence and connotation of TCM from microscopic system. That also can guide the research on optimum drug of TCM, predict new drug system and new unit of TCM, and finally to enrich clinical drugs.