中西医结合治疗小儿过敏性紫癜临床疗效观察

CLINICAL EFFECT OF WESTERN MEDICINE INTEGRATED WITH TRADITIONAL CHINESE MEDICINE IN THE TREATMENT OF CHILDREN WITH HENOCH-SCHONLEIN PURPURA

目的探讨中西医结合治疗小儿过敏性紫癜(HSP)的临床疗效。方法将确诊为HSP的64例患儿随机分为对照组和观察组,对照组32例患儿采用西药治疗,观察组32例患儿采用中西医结合治疗。二组患儿均治疗2个疗程。结果经过临床治疗后,对照组的患儿总有效率为75.0%,观察组的患儿总有效率为96.9%,组间比较差异有统计学意义(P<0.05),观察组临床疗效优于对照组。二组患儿在治疗过程中均未出现严重的不良反应。治疗后1年内随访过程中,对照组的复发率为35.7%,观察组的复发率为4.3%,组间比较差异有统计学意义(P<0.05),观察组的HSP复发率低于对照组。结论中西医结合治疗小儿HSP的临床疗效好,值得临床推广应用。

Objective To investigate the clinical effect of western medicine integrated with traditional Chinese medicine in the treatment of children with henoch-schonlein purpura（HSP）.Methods Totally 64 cases of children with HSP were randomly divided into two groups,32 children in each group.Control group was treated with western medicine,while treatment group treated with traditional Chinese medicine combined with western medicine.Both control group and treatment group were treated for two treatment courses.Results After two courses of treatment,the effective total rate of control group was 75.0%,while the effective total rate of treatment group was 96.9%,and there was significant difference in the effective total rate compared control group with treatment group（P〈0.05）by chi-square（χ2）test,the clinical effect of treatment group was better than control group.In the treatment process,seriously adverse did not appear in both control group and treatment group.In the one-year follow-up after clinical treatment,the recurrence rate of HSP in control group was 35.7%,while the recurrence rate of HSP in treatment group was 4.3%,and by Fisher exact probability test,there was significant difference in the recurrence rate of HSP compared control group with treatment group（P〈0.05）,and the recurrence rate of HSP in treatment group was lower than that in control group.Conclusion There is significant clinical effect of western medicine integrated with traditional Chinese medicine in the treatment of children with HSP.The treatment protocols is worthy of clinical popularization and application.