摘要
目的探讨南京地区慢性丙型肝炎患者丙型肝炎病毒(hepatitis C virus,HCV)基因型分布特征和相关的影响因素,以对HCV感染的控制和个体化治疗提供依据。方法收集南京市第二医院慢性丙型肝炎患者1 030例,采用基因芯片法检测HCV患者基因型,分析HCV基因型的组成及其与性别、年龄的关系。结果本研究中南京地区基因型有1a,1b,2a,3a,3b,6型和少量混合型,1b型占73.0%(752/1 030),其次为2a型占9.4%(97/1 030),未见4型和5型;在男女慢性HCV患者中,1b型均为主要基因型,1b型在男性组中比例明显高于女性组,差异有统计学意义(P<0.01);1b型与2a型患者平均年龄大于3b型患者,差异有统计学意义(P<0.01)。结论南京地区HCV基因型以1b型为主,其次为2a型,未见4型、5型;3b型患者的平均年龄均比1b型和2a型患者小。
Objective To provide evidence for controlling HCV infection and HCV-personalized medicine,the characterisitcs of hepatitis C virus（HCV）genotyping distribution in patients with chronic hepatitis C virus in Nanjing area and related factors were analyzed.Methods A total of 1 030 blood samples from chronic hepatitis C patients in the Second Hospital of Nanjing were collected.HCV genotyping was verified by gene chip.The relationships between HCV genotyping,gender and age were analyzed.Results Seven different HCV genotypes were found,including 1a,1b,2a,3a,3b,6and few mixed-genotypes,and genotypes 1band 2aaccounted for 73.0%（752/1 030）and 9.4%（97/1 030）,respectively.There were no genotypes 4and 5found in the study.Genotype 1b was the most common genotyping in both male and female patients,while the percentage of genotype 1bwas significantly higher in male than in female（P 〈0.01）.The average age of patients with genotype 1bor 2awas significantly older than that of genotype3b（P〈 0.01）.Conclusion HCV genotype 1b was the most common genotyping in Nanjing area,followed by genotype 2a.Genotypes including 1a,3a,3band 6 were found except for genotypes 4and 5.The average age of patients with genotype 3bis younger than that with genotype 1bor 2a.
出处
《临床荟萃》
CAS
2015年第4期393-396,共4页
Clinical Focus
基金
南京市医学科技发展项目(YKK13151
QRX11236)
