强直性脊柱炎合并多发性骨髓瘤1例并文献复习

Ankylosing spondylitis concurrent with multiple myeloma:a case report and literature review

强直性脊柱炎(ankylosing spondylitis,AS)是一种慢性炎症性疾病,主要侵犯骶髂关节、脊柱骨突、脊柱旁软组织及外周关节,并可伴发关节外表现,严重者可发生脊柱畸形和强直〔1〕。多发性骨髓瘤(multiple myeloma,MM)是起源于B细胞的恶性血液疾病,以骨髓中单克隆性浆细胞恶性增殖并合成和(或)分泌过量结构完全均一的M蛋白或其轻链为特征〔2〕。

Summary Reporting a case who was diagnosed as ankylosing spondylitis（AS） concurrent with multiple myeloma（ MM）, including the clinical characteristics, diagnosis and treatment, in the meantime, relevant literatures were reviewed. MM was confirmed in a patient who had long term stable AS. The clinical manifestations include a lump at humerus with persistent pain, pathologic fracture, anemia, kidney dysfunction and so on. This patient was treated with routine chemotherapy and Chinese traditional medicine, but had an unfavorable prognosis. Patients who are diagnosed as AS concurrent with MM can present with a variety of clinical features. Manifestations are difficult to explain clinically by AS and poor response to treatment. Patients have long-term stable AS are potential clues for MM.