地格达-4对酒精性脂肪肝模型大鼠肝功能的影响

Influences of Digda-4 over the Hepatic Function of Rats with Alcoholic Fatty Liver

目的:观察蒙药地格达-4对酒精性脂肪肝模型大鼠肝功能的影响。方法:将Wi st ar大鼠进行造模后随机分为空白组,模型组,硫普罗宁组和地格达-4高、中、低剂量组。空白组和模型组给以羧甲基纤维素钠,硫普罗宁组给予硫普罗宁40 mg/kg,地格达-4高、中、低剂量组分别给以1 400、700、350 mg/kg地格达-4。灌胃4周后,腹主动脉采血,检测谷丙转氨酶(ALT)、谷草转氨酶(AST)、γ-谷氨酰转移酶(γ-GT)等指标。结果:地格达-4高剂量组、中剂量组与模型组ALT相比,差异有统计学意义(P<0.05);地格达-4高、中、低剂量组间ALT相比,差异有统计学意义(P<0.05);地格达-4中剂量组与模型组、地格达-4高剂量组、低剂量组AST、γ-GT相比,差异有统计学意义(P<0.05);地格达-4高、中、低剂量组比硫普罗宁组γ-GT相比,差异有统计学意义(P<0.05)。结论:地格达-4对酒精性脂肪肝大鼠的肝功能有确切的保护作用,且中等剂量为首选剂量。

Objective： To study the effect of mongolian medicine digda-4 on the hepatic function of rats with alcoholic fatty liver. Methods： After established, the wistar rats model were randomized into the blank group and the model group, the tiopronin group as well as the digda-4 group of low, medium and high dosages. The blank and model groups were given carboxymethyl cellulose natrium; the tiopronin group were administered tiopronin, 40 mg/kg; the low, medium and high digda-4 groups were respectively fed digda-4 of 1 400,700 and 350 mg/kg. After 4-week gavage, alanine aminotransferase （ALT）, aspartate transaminase （AST） and 3,-glutamyl transferase（Y-GT） were tested in the rats＇ blood samples collected from abdominal aorta. Results： Compared with model group, the ALT contents in the digda-4 groups of high and medium doses had a significant difference （P〈0.05）; among the digda-4 groups of low, medium and high doses, the ALT contents were significantly different either （P〈0.05）; com- pared with the model group and the digda-4 groups of high and low doses, the contents of AST and T-GT in the dig- da-4 group of medium doses had significant differences （P〈0.05）; compared with the tiopronin group, the T-GT contents in the digda-4 group of low, medium and high dosages had a significant difference （P〈0.05）. Conclusion： Digda-4 has definitely protective effect on hepatic function of rats with alcoholic fatty liver, and the medium dose is preferred.