ICU产ESBLs大肠埃希菌和肺炎克雷伯菌耐药性分析

ANALYSIS OF DRUG RESISTANCE OF ESBLS ESCHERICHIA COLI AND KLEBSIELLA PNEUMONIAE IN ICU

目的探讨医院重症监护病房产超广谱β-内酰胺酶（ESBLs）大肠埃希菌和肺炎克雷伯菌的耐药性。方法采用BD Phoenix100全自动微生物分析仪对莒县中医医院重症监护病房产超广谱β-内酰胺酶（ESBLs）大肠埃希菌和肺炎克雷伯菌进行细菌鉴定和药物敏感试验。结果产ESBLs大肠埃希菌和肺炎克雷伯菌均呈现多重耐药,大肠埃希菌对亚胺培南、哌拉西林/他唑巴坦和阿米卡星的耐药率分别为1.8%、5.5%和20.0%,其余14种抗生素的耐药率在54.6%~100.0%;肺炎克雷伯菌对亚胺培南无耐药现象,其余16种抗生素的耐药率在56.0%~100.0%。结论重症监护病房分离的产ESBLs大肠埃希菌和肺炎克雷伯菌多重耐药严重;同样是产ESBLs菌株,大肠埃希菌和肺炎克雷伯菌对相同抗生素的敏感率明显不同。

Objective To explore the drug‐resistance of extended spectrum β‐lactamases（ESBLs） Esche‐richia coli and Klebsiella pneumoniae isolated from ICU .Methods BD phoenix 100 automatic microbial ana‐lyzer was used for species identification and drug sensitivity test .Results ESBLs Escherichia coli and Kleb‐siella pneumoniae exhibited multiple‐drug resistance . T he drug resistance rates of Escherichia coli to imipen‐em ,piperacillin/tazobactam and amikacin were 1 .8% , 5 .5% and 20 .0% respectively . T he drug resistance rates of Escherichia coli to other 14 antibiotics ranged＆amp;nbsp;from 54 .6% to 100 .0% .Klebsiella pneumoniae showed no drug resistance to imipenem .The resistance rate of Klebsiella pneumoniae to other 16 antibiotics ranged from 56 .0% to 100 .0% .Conclusion The mul‐tiple‐drug resistance of ESBL Escherichia coli and Klebsiella pneumoniae isolated from ICU samples is se‐vere ,but the resistant rates of Escherichia coli and Klebsiella pneumoniae to the same antibiotics are obvi‐ously different .