通过带有裸露羧酸根的Suzuki反应合成联苯羧酸衍生物的研究

Synthesis of biphenylcarboxylic acid derivatives using suzuki coupling reaction with free carboxylic acid

Suzuki偶联反应是合成联苯结构的重要方法之一,本文以溴带芳烃和有机硼酸酯为原料,尝试了带有裸露羧酸根的Suzuki反应,并以62%的产率得到了联苯羧酸衍生物。这为联苯衍生物以及含有联苯结构的生物活性分子的快速生产提供了更为多样化的合成路线,为有效地推动联苯结构化合物的工业化生产做出了贡献。

As Suzuki coupling reaction was an important method for the synthesis of biphenyl structure, a route to biphenylcarboxylic acid derivatives was reported in the highest yield 62% through Suzuki reaction utilizing aryl bromine amt orgauic boronic acid ester as the raw material, which featuring the free earboxylic acid. Furthermore, the approach could provide more choice for rapid synthesis of biphenyl derivatives and biological activity molecules containing a biphenyl structure and make a contribution to promote industrial production of biphenyl derivatives.