还原型谷胱甘肽对早期糖尿病患者尿白蛋白排泄率及炎性因子的影响

Study on the Effect of Reduced Glutathione on Urine Albumin Excretion Rate and Inflammatory Factors in Patients with Early Diabetes

目的分析还原型谷胱甘肽对早期糖尿病患者尿白蛋白排泄率及炎性因子的影响。方法选择2012年9月至2013年7月屯昌县人民医院收治的早期糖尿病肾病患者76例,采用随机数字表法分为观察组与对照组,各38例。观察组给予1.2 g还原型谷胱甘肽静脉滴注,每日1次,连续治疗28 d;对照组给予1.2 g血塞通针静脉滴注,每日1次,连续治疗28 d。同期选取38例健康体检者作为正常对照组,未给予治疗措施。对比分析治疗前及治疗28 d后3组受试者血清白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)、C反应蛋白(CRP)水平,以及早期糖尿病肾病患者的尿白蛋白排泄率(UAER)。结果治疗前,观察组与对照组患者的血清IL-6、TNF-α及CRP水平均显著高于正常对照组(P<0.01)。治疗28 d后,观察组血清IL-6、TNF-α及CRP水平显著下降(P<0.01)。观察组治疗前后UAER水平分别为(160±28)mg和(106±24)mg,治疗前后比较差异有统计学意义(P<0.01)。结论还原型谷胱甘肽能减轻早期糖尿病肾病患者的炎症状态,延缓糖尿病肾病的进展。

Objective To analyze the effects of reduced glutathione on urine albumin excretion rate and inflammatory factors in patients with early diabetes.Methods A total of 76 patients with early diabetic nephropathy admitted in Tunchang County People＇ s Hospital from Sep.2012 to Jul.2013 were randomly divided into observation group and control group,with 38 cases in each group.Patients in the observation group were given intravenous infusion of 1.2 g glutathione,once per day,continuous treatment for 28 d,while patients in the control group received intravenous injection of 1.2 g Xuesaitong,once per day,continuous treatment for 28 d.Meanwhile,another 38 healthy people underwent physical examination during the same period were selected as normal control group.The serum levels of interleukin 6（IL-6）,tumor necrosis factor alpha（TNF-α）,C reactive protein（CRP） of the three groups before treatment and 28 days after treatment,and urinary albumin excretion rate（UAER） in those patients with early diabetic nephropathy before treatment and 28 d after treatment were comparatively analyzed.Results Before treatment,serum levels of IL-6,TNF-α and CRP in the observation group and the control group were significantly higher than those in normal control group（P〈0.01）,and 28 d after treatment,such levels of the observation group decreased significantly（P〈0.01）.Levels of UAER before and after treatment in the observation group were（160 ± 28） mg/and（106 ± 24） mg,the difference was statistically significant（P〈0.01）.Conclusion Reduced glutathione can alleviate the inflammatory status in patients with early diabetic nephropathy,and effectively slow down the progression of early diabetic nephropathy.