TEAS辅助硝普钠控制性低血压对Glu、ATⅡ及SOD的影响

Effects of transcutaneous electrical acupoint stimulation assisting sodium nitroprusside controlled hypotension on Glu,ATⅡ and SOD

目的通过观察经皮穴位电刺激（TEAS）辅助硝普钠控制性低血压对血糖（Glu）、血管紧张素Ⅱ（ATⅡ）及超氧化物歧化酶（SOD）的影响,探讨控制性低血压麻醉下TEAS对机体的保护作用。方法将择期静吸复合全身麻醉下采用硝普钠控制性降压行鼻内镜手术患者60例,维持平均动脉血压（MAP）在50-60mm Hg,随机等分为两组,Ⅰ组进行TEAS,Ⅱ组不进行TEAS。分别记录两组患者降压时间、手术时间,麻醉前（T0）、降压后30min（T1）、停降压时（T2）3个时点Glu和ATⅡ水平,T0、T2、停降压后30min（T3）3个时点SOD水平。结果两组患者手术时间、控制降压持续时间比较,差异无统计学意义（P〉0.05）;Glu水平Ⅰ组3个时点差异无统计学意义（P〉0.05）,Ⅱ组T1、T2时点较T0时点升高（P〈0.05）,T1、T2时点Ⅱ组均比Ⅰ组高（P〈0.05）;ATⅡ水平Ⅰ组T1时点较T0时点升高（P〈0.05）,Ⅱ组T1、T2时点较T0时点升高（P〈0.05）,T1、T2时点Ⅱ组均比Ⅰ组高（P〈0.05）;SOD水平Ⅰ组T2时点较T0时点降低（P〈0.05）,Ⅱ组T2、T3时点较T0时点降低（P〈0.05）,T2、T3时点Ⅱ组均比Ⅰ组低（P〈0.05）。结论 TEAS辅助硝普钠控制性低血压能较好地抑制应激反应。

Objective To observe the effects of transdermal acupoint electric stimulation（TEAS）assisting sodium nitroprusside induced controlled hypotension on serum glucose（Glu）,angiotensinⅡ（ATⅡ）and superoxide dismutase（SOD）,and to investigate the protective effect of TEAS under controlled hypotension anesthesia.Methods 60 cases undergoing elective endoscopy sinus surgery by adopting sodium nitroprusside induced controlled hypotension under general anaesthesia maintained the mean arterial pressure（MAP）in 50-60 mm Hg and were randomly and equally divided into two groups.The group Ⅰ conducted TEAS,while the group Ⅱ did not conduct TEAS.The controlled hypotension time and surgery time were recorded in the two groups;Glu and ATⅡ values were detected before anesthesia（T0）,30 min after hypotension（T1）,hypotension stopping（T2）;SOD was detected at T0,T2,30 min after hypotension（T3）.Results The operation time and controlled hypotension continuous time had no statistically significant difference between the two groups（P〈0.05）.The Glu value in the groupⅠ had no statistically significant difference among the 3time points,while which at T1,T2 was higher than that at T0 in the group Ⅱ（P〈0.05）,and which at T1,T2 in the group Ⅱ was higher than that in the group Ⅰ（P〈0.05）;the ATⅡ value at T1 was higher than that at T0 in the group Ⅰ（P〈0.05）,while which at T1,T2 was higher than that at T0 in the groupⅡ（P〈0.05）,which at T1,T2 in the groupⅡ was higher than that in the groupⅠ（P〈0.05）;the SOD value at T2 was lower than that at T0 in the groupⅠ,which at T2,T3 in the groupⅡ was lower than that in the groupⅠ（P〈0.05）.Conclusion TEAS assisting sodium nitroprusside controlled hypotension can better inhibit the stress response.