妊娠期糖尿病与血硒水平及谷胱甘肽过氧化酶活性的研究

Study on blood selenium level and glutathione peroxidase activity in gestational diabetes mellitus

目的研究血硒水平及谷胱甘肽过氧化酶(GSH-Px)与妊娠期糖尿病(GDM)发生的关系。方法选择2011年1月至2012年12月就诊于该院的孕妇共1 360例,其中68例为GDM患者(观察组),另随机抽取非GDM孕妇113例作为对照组,对比两组患者血清中的血硒水平及GSH-Px活性。结果对照组血硒水平及GSH-Px活性均高于观察组,对照组与观察组血硒水平分别为(3.07±0.51)、(2.06±0.41)mmol/L,GSH-Px活性分别为(197.23±18.73)、(151.35±19.67)U,两组比较差异有统计学意义(P<0.05)。结论血硒水平及抗过氧化酶活性降低可能是GDM的发病原因之一。

Objective To study the correlation between the blood selenium level and glutathione peroxidase（GSH-Px）with the occurrence of gestational diabetes mellitus（GDM）.Methods Among 1 360 pregnant women in our hospital from January 2011 to December 2012,68 cases GDM were diagnosed as GDM（observation group）and other 113non-GDM pregnant women were randomly selected from these 1360 pregnant women as the control group.The serum selenium level and GSH-Px activity were compared between the two groups.Results The selenium level and GSH-Px activity in the control group were higher than those in the observation group.The selenium level was（3.07±0.51）mmol/L in the control group and（2.06±0.41）mmol/L in the observation group,respectively;the GSH-Px activity was（197.23±18.73）U in the control group and（151.35±19.67）U in the observation group,the differences between the two groups were statistically significant（P〈0.05）.Conclusion The decrease of serum selenium level and GSH-Px activity may be one of the pathogenic causes of GDM.