血浆置换治疗抗-NMDA受体脑炎的临床应用

The clinical application of plasma exchange treatment on the resistance of NMDA receptor in encephalitis

目的探讨血浆置换联合其它药物治疗抗-NMDA受体脑炎的应用和临床疗效。方法 1例确诊为抗-NMDA受体脑炎的患者应用血细胞离心机进行血浆置换(2-3)次/周,共进行6次治疗。治疗前后做血常规、电解质、血浆蛋白检测。结果治疗后患者球蛋白从(56.75±55.65)g/L下降至(44.52±40.11)g/L(P<0.05);白蛋白/球蛋白比值从(1.14±0.77)升高至(1.28±0.79)(P<0.01),差异有统计学意义。且患者临床症状较血浆置换前减轻,脑脊液NMDA受体抗体阳性强度减弱。结论血浆置换治疗抗-NMDA受体脑炎有效。

Objective To investigate the application of plasma exchange in combination with other drugs and to study its clinical curative effect on NMDA receptor encephalitis. Methods One case was diagnosed as an NMDA receptor encephalitis. Patient＇s blood was centrifuged and underwent plasma exchange for 2 to 3 times per week,for a total of 6 times. Results Globulin decreased from（ 56. 75 ± 55. 65） g / L to（ 44. 52 ± 40. 11） g / L（ p〈 0. 05）. The ratio of albumin / globulin increased from（ 1. 14 ± 0. 77） to（ 1. 28 ± 0. 79）（ p 0. 01）. Clinical symptoms were alleviated in patients,in addition to the reduction in strength of NMDA receptor antibody in cerebrospinal fluid. Conclusion Plasma exchange treatment is effective for NMDA receptor encephalitis.