清肺止痉活血法治疗小儿支原体肺炎痰热闭肺证的临床疗效及其对血小板、D-二聚体的影响

Efficacy of Qingfei Zhijing Huoxue method for children mycoplasma pneumoniae pneumonia with syndrome of phlegm-heat obstructing lung and its effects on blood platelet and D-Dimer

目的观察中药清肺止痉活血方联合阿奇霉素治疗小儿支原体肺炎(MPP)痰热闭肺证的临床疗效及其对血小板(PLT)、D-二聚体的影响。方法将60例患儿随机分为治疗组和对照组各30例,治疗组采用中药清肺止痉活血方联合阿奇霉素静脉滴注;对照组仅采用阿奇霉素静脉滴注,2组均辅以西医对症治疗。比较2组患儿治疗前后主要、次要症状体征评分,血小板(PLT)、C反应蛋白(CRP)、凝血四项(PT、APTT、FIB、TT)、D-聚体,以及临床总疗效。结果 2组总体疗效,咳嗽、痰壅、气喘、听诊啰音等主症,精神、面色、食欲食量、口渴等次症,以及PLT、D-二聚体、FIB等指标,组间比较差异均有统计学意义(P<0.05)。结论清肺止痉活血法联合阿奇霉素治疗痰热闭肺证MPP,可改善和预防患儿的高凝状态,提高临床疗效。

Objective To observe the clinical efficacy of traditional Chinese medicine（ TCM） Qingfei Zhijing Huoxue Decoction combined with azithromycin for children mycoplasma pneumoniae pneumonia（ MPP） and its effects on blood platelet（ PLT） and D-Dimer. Methods Sixty cases were randomly divided into a treatment group and a control group,30 cases in each. Children in treatment group were treated with intravenous drip of TCM Qingfei Zhijing Huoxue Decoction combined with azithromycin, while children in the control group were treated with intravenous drip of azithromycin. Western medicine was given according to symptoms in both groups. The primary symptoms, secondary symptoms, syndrome score, laboratory indexes and total clinical efficacy were compared before and after treatment in two groups. Results The differences of total clinical efficacy,primary symptoms,secondary symptoms,PLT,D-Dimer and FIB between two groups were statistically significant（ P〈0. 05）. Conclusion Qingfei Zhijing Huoxue method combined with azithromycin could improve and prevent hypercoagulable state and improve clinical efficacy in children MMP with syndrome of phlegm-heat obstructing lung.