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人附睾蛋白4(HE4)在恶性肿瘤中的表达与临床进展 被引量：18

Expression of Human Epididymis Protein 4 in Cancer and its Clinical Progress
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摘要 人附睾蛋白4(human epididymis protein-4,HE4)是具有免疫保护作用的蛋白酶抑制剂家族的成员,可在血清及组织中检测到其表达,在正常组织中呈低表达,在肿瘤组织中呈高表达。目前,国内外已有多项研究表明HE4与卵巢癌、子宫内膜癌、肺癌、膀胱癌等肿瘤有关,且其敏感度与特异性均优于CA125,美国FDA已批准将其作为一个新的肿瘤标志物用于卵巢肿瘤的疗效及复发的监测。本文主要对HE4在各种恶性肿瘤中的表达与临床应用进展进行综述。 Human epididymis protein 4（HE4） is one member of the protease inhibitor family which have the immune protective effect. It can be detected in serum and tissues, presenting low expression in normal tissues but over expression in tumor tissues. Nowadays, numerous studies showed that HE4 has relationship with ovarian cancer, endometrial cancer, lung cancer and bladder cancer, etc. Besides, since it has a higher sensitivity and specificity than CA125, HE4 has been approved by FDA as a new tumor marker for diagnosis of ovarian cancer in early stage. In this article, we reviewed the expression patterns of HE4 in various malignant neoplasms and its clinical application progress.
作者 唐雨曦 罗晨辉 王瑛 王静
机构地区 南华大学 湖南省肿瘤医院 中南大学湘雅医学院附属肿瘤医院
出处 《肿瘤药学》 CAS 2015年第2期87-91,共5页 Anti-Tumor Pharmacy
基金 湖南省科技厅重点项目资助(2013FJ2009)
关键词 人附睾蛋白4 卵巢癌 子宫内膜癌 肿瘤标志物 HE4 Ovarian cancer Endometrial cancer Tumor maker
分类号 R730.3 [医药卫生—肿瘤]
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参考文献26

  • 1Kirchhoff C, Habben I, Ivell R, et al. A major human epididymis-specific cDNA encodes a protein with sequence homology to extracellular proteinase inhibitors [J]. Biol Re- prod, 1991, 45(2): 350-357.
  • 2Bingle L, Singleton V, Bingle CD. The putative ovarian tumour marker gene HE4 (WFDC2), is expressed in nor- real tissues and undergoes complex alternative splicing to yield multiple protein isoforms [Jl. Oncogene, 2002, 21(17): 2768-2773.
  • 3Kong X, Chang X, Cheng H, et al. Human epididymis pro- tein 4 inhibits proliferation of human ovarian cancer cells via the mitogen-activated protein kinase and phosphoinositide 3-kinase/AKT pathways [J]. Int J Gynecol Cancer, 2014, 24(3): 427-436.
  • 4Gao L, Cheng HY, Dong L, etal. The role of HE4 in ovarian cancer: inhibiting tumour cell proliferation and metastasis [J]. J Int Med Res, 2011, 39(5): 1645-660.
  • 5Lu R, Sun X, Xiao R,et al. Human epididymis protein 4 (HE4) plays a key role in ovarian cancer cell adhesion and motility [J]. Biochem Biophys Res Commun, 2012, 419(2): 274-280.
  • 6Galgano MT, Hampton GM, Frierson HF Jr. Comprehensive analysis of HE4 expression in normal and malignant human tissues [J]. Mod Pathol, 2006, 19(6): 847-853.
  • 7Nagy B Jr, Krasznai ZT, Balla H, et al. Elevated human epididymis protein 4 concentrations in chronic kidney disease [J]. Ann Clin Biochem, 2012, 49(Pt 4): 377-380.
  • 8LeBleu VS, Teng Y, O'Connell JT, et al. Identification of human epididymis protein-4 as a fibroblast-derived me- diator of fibrosis [J]. Nat Med, 2013, 19(2): 227-231.
  • 9Schummer M, Ng WV, Bumgarner RE, et al. Comparative hybridization of an array of 21,500 ovarian cDNAs for the discovery of genes overexpressed in ovarian carcinomas [J]. Gene, 1999, 238(2): 375-385.
  • 10Moore RG, Brown AK, Miller MC, et al. The use of multiple novel tumor biomarkers for the detection of ovarian carcino- ma in patients with a pelvic mass [J]. Gynecol Oncol, 2008, 108(2): 402-408.

二级参考文献19

  • 1徐元斌 王德春 等.恶性肿瘤特异性生长因子（TSGF）测定及临床应用[J].福建医学检验,1996,1(3):118-118.
  • 2Kirchhoff C,Habben I,Ivell R,et al.A major human epididymis-specific cDNA encodes a protein with sequence homology to extracellular proteinase inhibitors[J].Biol Reprod,1991,45(2):350-357.
  • 3Galgano MT,Hampton GM,Frierson HF Jr.Comprehensive analysis of HE4 expression in normal and malignant human tissues[J].Mod Pathol,2006,19(6):847-853.
  • 4Bingle L,Cross SS,High AS,et al.WFDC2 (HE4):a potential role in the innate immunity of the oral cavity and respiratory tract and the development of adenocarcinomas of the lung[J].Respir Res,2006,7:61.
  • 5Bingle L,Singleton V,Bingle CD.The putative ovarian tumour marker gene HE4 (WFDC2),is expressed in normal tissues and undergoes complex alternative splicing to yield multiple protein isoforms[J].Oncogene,2002,21(17):2768-2773.
  • 6Moore RG,Brown AK,Miller MC,et al.Utility of a novel serum tumor biomarker HE4 in patients with endometrioid adenocarcinoma of the uterus[J].Gynecol Oncol,2008,110(2):196-201.
  • 7Huhtinen K,Suvitie P,Hiissa J,et al.Serum HE4 concentration differentiates malignant ovarian tumours from ovarian endometriotic cysts[J].Br J Cancer,2009,100(8):1315-1319.
  • 8Galgano MT, Hampton GM,Frierson HF. Comprehensive analysls of HE4 expressbm in normal and maligrant hu- man tissue[J]. Mod Pathol,2006,19(6):847-853.
  • 9Kirchhoff C, Habben I,Ivell R,et al. A major human epididymis- specific cDNA encodes a protein with sequence homology to ex- tracellular proteinase inhibitors[J]. Biol Reprod, 1991,45 :350.
  • 10Moore RG,Brown AK,Miller MC,et al. Utility of a novel serum tumor biomarker HE4 in patients with endometrioid adenocarci noma of the uterus[J]. Gynecol Oneol, 2008,110 : 196.

共引文献36

同被引文献113

引证文献18

二级引证文献78

肿瘤药学
2015年 第2期

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