中国人群H型高血压与脑梗死关系的Meta分析

Relationship Between H-type Hypertension and Cerebral Infarction in Chinese Population: A Meta-analysis

目的综合评价中国人群H型高血压与脑梗死的关系。方法计算机检索Pub Med、Web of Science、中国学术期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、维普中文科技期刊数据库(VIP)和万方数据库(Wanfang Database),收集有关中国人群H型高血压与脑梗死关系的病例对照研究,病例组为脑梗死患者,对照组为非脑梗死患者,检索时限为从各数据库建库至2015年1月。由2名研究人员独立提取资料并评价纳入文献的质量,采用Rev Man 5.2软件进行Meta分析。结果共纳入9篇文献进行Meta分析,均为中文文献。结果显示,病例组H型高血压发病率与对照组比较,差异有统计学意义〔OR=2.50,95%CI(1.59,3.91),P<0.05〕。H型高血压与急性脑梗死〔OR=2.65,95%CI(1.52,4.63),P<0.05〕和无症状脑梗死〔OR=2.10,95%CI(1.14,3.87),P<0.05〕的发生均相关。亚组分析结果表明,年龄>60岁的人群中,病例组H型高血压发病率与对照组间差异有统计学意义〔OR=2.27,95%CI(1.41,3.66),P<0.05〕。敏感性分析与发表偏倚分析表明本研究结果稳定、可靠。结论脑梗死患者与非脑梗死患者相比,H型高血压发病率更高,提示中国人群H型高血压与脑梗死关系密切,H型高血压患者可能更易患脑梗死。

Objective To evaluate the association between H-type hypertension and cerebral infarction in Chinese population. Methods The relevant case-control studies were identified by searching Pub Med, Web of Science, CNKI,CBM,VIP and Wanfang Database up to January 2015. Case group was cerebral infarction patients,control group was non-cerebral infarction patients. Data extraction and quality assessment were completed by two authors. All the analyses were conducted with Rev Man 5. 2 software. Results A total of 9 literatures in Chinese were included in this Meta-analysis. The pooled analysis showed that case group and control group were significantly 〔OR = 2. 50,95% CI（ 1. 59,3. 91）,P〈0. 05 〕different in H-type hypertension rate. Both acute cerebral infarction 〔OR = 2. 65,95% CI（ 1. 52,4. 63）,P〈0. 05 〕 and silent cerebral infarction 〔OR = 2. 10,95% CI（ 1. 14,3. 87）, P〈0. 05 〕 were associated with H-type hypertension.Subgroup analysis showed significant 〔OR = 2. 27,95% CI（ 1. 41,3. 66）, P〈0. 05 〕 difference between case group and control group in H-type hypertension rate in patients 〉60 years old. Sensitivity analysis and publication bias outcomes reflected that our results were statistically stable and reliable. Conclusion Compared with non-cerebral infarction patients,cerebral infarction patients have a higher morbidity of H-type hypertension. Cerebral infarction may be closely associated with H-type hypertension in Chinese population and patients with H-type hypertension are more likely to have cerebral infarction.