抑郁状态患者事件相关电位P300的特点研究

Characteristics of Event Related Potential P300 in Patients With Depression

目的分析抑郁状态患者事件相关电位P300(ERP-P300)的特点,探讨抑郁状态患者认知功能障碍情况。方法选取2013年6月—2014年6月在北京大学人民医院神经内科就诊的患者75例,按照患者是否存在抑郁状态分为抑郁状态组40例和对照组35例,两组患者均进行简易智能精神状态评价量表(MMSE)和ERP-P300检测,记录P300波的潜伏期和波幅。结果两组患者性别、年龄、职业性质、文化程度、记忆力下降时间比较,差异均无统计学意义(P>0.05)。两组MMSE评分均在参考范围内,但对照组MMSE量表评分高于抑郁状态组(P<0.05)。抑郁状态组中央区、顶区ERP-P300潜伏期较对照组延长,中央区、顶区ERP-P300波幅较对照组降低(P<0.05)。抑郁状态组、对照组患者年龄均与ERP-P300潜伏期呈正相关(r=0.481、0.351,P<0.05)。结论抑郁状态患者ERP-P300潜伏期延长,波幅降低,患者存在认知功能障碍,P300是临床评价抑郁状态患者认知功能障碍的有效工具。

Objective To analyze the characteristics of event related potential P300（ ERP-P300） in patients with depression and to evaluate the status of their cognitive dysfunction. Methods This study enrolled 75 patients who received treatment in the Department of Neurology,the People＇s Hospital of Peking University from June 2013 to June 2014. Among them,40 patients with depression were assigned as depression group and other 35 patients without depression as control group. Mini-mental state examination（ MMSE） scale was employed on the two groups. ERP-P300 test was conducted to record the latency period and amplitude of P300 wave. Results The two groups had no significant difference in gender, age, occupation,education level,length of memory deterioration（ P〉0. 05）. Scores of the two groups were within normal range,while MMSE scores of control group were higher（ P〈0. 05）. The depression group showed longer latency and shorter amplitude of ERP-P300 in central region and parietal region（ P〈0. 05）. Age was positively correlated with latency period of ERP-P300 for both groups（ r = 0. 481,0. 351,P〈0. 05）. Conclusion Patients with depression show longer latency and shorter amplitude of ERP-P300, patients have cognitive dysfunction. P300 is an effective tool for clinical evaluation of cognitive dysfunction in patients with depression.