补阳还五汤加减治疗急性脑梗死的临床疗效

Clinical Effect of Buyang Huanwu Decoction on Acute Cerebral Infarction

目的观察补阳还五汤加减治疗急性脑梗死的临床疗效。方法选择2010年1月—2013年10月广州市第十二人民医院神经内科收治的急性脑梗死患者120例,随机分为研究组和对照组,各60例。对照组患者给予常规治疗,研究组患者在常规治疗基础上给予补阳还五汤加减治疗,均治疗2周。比较两组患者临床疗效,治疗前及治疗第7、14、21天改良爱丁堡-斯堪的那维亚评分量表(MESSS)评分及心肝肾功能变化,治疗前及治疗第7、21、30、90天改良的Barthel指数(BI)评分。结果研究组患者临床疗效优于对照组(P<0.05)。两组患者治疗前、治疗第7天MESSS评分比较,差异无统计学意义(P>0.05);研究组患者治疗第14、21天MESSS评分低于对照组(P<0.05)。两组患者治疗前和治疗第7天改良的BI评分比较,差异无统计学意义(P>0.05);研究组患者治疗第21、30、90天改良的BI评分高于对照组(P<0.05)。两组患者治疗前及治疗后第7、14、21天心、肝、肾功能均无明显异常。结论补阳还五汤加减治疗急性脑梗死疗效良好,能有效改善患者神经功能损伤程度及生活自理能力,且安全性高。

Objective To observe the clinical effect of buyang huanwu decoction on acute cerebral infarction.Methods A total of 120 patients with acute cerebral infarction were selected in the Department of Neurology, the Twelfth Hospital of Guangzhou,from January 2010 to October 2013,and they were randomly divided into groups study and control,each of 60 cases. Both groups were given conventional therapy,while study group was given extra buyang huanwu decoction,treated for 2 weeks. Clinical effect,MESSS score as well as heart,liver,kidney function before treatment and 7 days,14 days,21 days after treatment,modified BI score before treatment and 7 days,21 days,30 days,90 days after treatment were compared between the two groups. Results The clinical effect of study group was better than that of control group（ P〈0. 05）. No statistically significant differences of MESSS score was found between the two groups before treatment or 7 days after treatment（ P〈0. 05）; while MESSS score of study group was lower than that of control group 14 days,21 days after treatment,respectively（ P〈0. 05）. No statistically significant differences of modified BI score was found between the two groups before treatment or 7days after treatment（ P〈0. 05）; while modified BI score of study group was higher than that of control group 21 days,30 days,90 days after treatment,respectively（ P〈0. 05）. No one of the two groups occurred any obvious abnormity of heart,liver,kidney function before treatment and 7 days,14 days,21 days after treatment. Conclusion Buyang huanwu decoction has good clinical effect on acute cerebral infarction,can effectively improve the degree of nerve function deficits and self-care ability of daily living,and is safe.