幽门螺杆菌阴性十二指肠溃疡的临床分析

Clinical analysis of helicobacter pylori negativeduodenal ulcer

目的总结十二指肠溃疡中幽门螺旋杆菌(HP)阴性患者的临床特征,以为临床诊治提供参考。方法以30例HP阴性的十二指肠溃疡患者作为阴性组,以50例HP阳性的十二指肠溃疡患者作为阳性组。回顾性分析两组的临床资料,进行回顾性分析,分析两组临床发病特点、临床症状特点及理化检查特征。结果两组间职业及性别间无统计学差异(P>0.05),但阴性组年龄>60岁患者发病率明显高于阳性组(P<0.05)。两组临床症状方面比较无统计学差异(P>0.05)。而胃镜下溃疡直径比较无统计学差异(P>0.05),但阴性组平均溃疡数目明显高于阳性组(P<0.05),且病理学检查中,阴性组肠化生及非典型增生发生率明显高于阳性组(P<0.05)。结论 HP阴性的十二指肠溃疡患者有其独特的临床特征,临床可将其作为鉴别诊断的参考。

Objective This paper was to summarize the clinical features of Helicobacter pylori （ HP ） negative patients with duodenal ulcer, and provide reference for clinical diagnosis and treatment.Methods 30 cases of HP-negative patients with duodenal ulcer were chose as a negative group, 50 cases of HP-positive duodenal ulcer patients were selected as positive group.A retrospective analysis was done on the clinical datas, and the analysis focused on disease characteristics, clinical symptoms and physical and chemical characteristics of checking features.Results The difference of construction of occupation andsex of the two groups was notstatistically significant（P〉 0.05）.The incidence ofduodenal ulcer in those over 60 years in the negative group was significantly higher than the positive group （ P 〈 0.05 ） .There was no significant difference on clinical symptoms and diameter of ulcers between the two groups（P〉 0.05）.The average number of ulcers in negative group was significantly higher than that of the positive-negative group （P〈 0.05）.The incidence of intestinal metaplasia and dysplasia in negative group was higher than the positive group （P〈 0.05）.Conclusions HP-negative patients with duodenal ulcer has its unique clinical features, clinical differential diagnosis can be used as a reference.