卡泊三醇与卤米松序贯疗法治疗稳定期．斑块状银屑病的疗效与安全性

Efficacy and safety of calcipotriene and halometasone sequential therapy for plaque psoriasis at stable stage

目的探讨稳定期斑块状银屑病患者应用卡泊三醇与卤米松序贯疗法的临床疗效与安全性。方法选取2013年2月至2014年3月漯河市第二人民医院收治的90例稳定期癍块状银屑病患者为研究对象，随机将其分为对照A、B组以及实验组，每组30例，给予对照A组卡泊三醇外用，对照B组给予卤米松外用，实验组联用卡泊三醇与卤米松14周后评估三组治疗效果。结果对照A、B组间治疗效果比较差异未见统计学意义（P〉0．05）；与对照A、B两组相比，实验组治疗有效率更高，组间差异有统计学意义（P〈0．05）。结论对于稳定期斑块状银屑病患者而言,卡泊三醇与卤米松序贯疗法是其临床治疗过程中疗效确切、不易复发且不良反应较少的一种治疗方案，值得临床推广和应用。

Objective To investigate the efficacy and safety of calcipotriene and halometasone sequential therapy for plaque psoriasis at stable stage. Methods From February 2013 to March 2014, 90 patients with plaque psoriasis at stable stage in our hospital were randomly divided into control A group, control B group, and the experimental group, with 30 patients in each group. The patients in control group A were treated with calcipotriene topical, the patients in control group B were treated with halometasone topical, and the patients in experimental group were treated with calcipotriene and halometasone seqtlential therapy. The effects of the three groups were assessed. Results There was no significant difference in the effects between the control group A and control group B （P 〉 0. 05）. Compared with the control group A and control group B, the experimental group had higher treatment efficiency, there were significant differences （P 〈 0：05 ）. Conclusions For patients with stable plaque psoriasis, calcipotfiol and halometasone sequential therapy has good effect, less recurrence and fewer adverse reactions, so is worthy to be promoted in clinics.