纳美芬在治疗一氧化碳中毒迟发性脑病的疗效分析

Efficacy of nalmefene on DEACMP

目的观察纳美芬在治疗急性一氧化碳中毒迟发性脑病所起的作用。方法对照组和实验组各100例均从200例患者中随机抽取。对照组采用一般常规治疗包括高压氧治疗，而实验组在对照组的基础上使用纳美芬治疗。观察两组的治疗效果，并通过应用蒙特利尔认知评估表（MoCA）和简易精神状态评估量表（MMSE）来评估所有患者用药前后的认知功能。结果实验纽的总有效率（94％）明显高于对照组（72％），两组比较差异有统计学意义（Х^2=9．524，P=0．002）；在MoCA和MMSE评分方面，其两组在经过治疗后分值均显著优于治疗前（P〈0．05），且与对照组相比较，实验组分值较高（P〈0．05）。结论新型药物纳美芬在一氧化碳中毒迟发性脑病的治疗上效果显著，在改善患者的认知功能障碍方面效果明显。

Objective To observe the curative effects of nalmefene on delayed encephalopathy after acute carbon monoxide poisoning（DEACMP）. Methods Two hundred patients were randomly divded into control group（ n= 100 ）and experimental group（ n = 100 ）by stratified randomization method. Both of the groups were given routine therapy including hyperbaric oxygen treatment, and experimental group was treated with nalmefene in addition. The clinical curative effect of the two groups were compared after clinical treatment, the patients＇ scores before treatment and after treatment were assessed by mini mental state examination（MMSE） and montreal cognitive assessment scale（MoCA）. Results The total effective rate of experimental group（94% ）was higher than that of control group（72% ）. For MoCA and MMSE, the scores after treatment were higher than that before treatment in the two groups （P 〈 0.05 ） , and the scores of experimental group was higher than that of the control group （P 〈 0.05 ）. Conclusions Nalmefene in the treatment of delayed encephalopathy after acute caebon monoxide poisoning（DEACMP） may have good effect and could obviously improve the cognitive dysfunction of the patients.