艾地苯醌联合灯盏细辛治疗血管性痴呆的疗效和安全评价

Efficacy and safety evaluation of idebenone combined with erigeron breviscapus in treatment of vascular dementia

目的探讨艾地苯醌联合灯盏细辛治疗血管性痴呆的的疗效和安全性。方法对确山县人民医院2012年1月1日至2014年1月1日收治的200例血管性痴呆患者的临床资料进行分析。将单纯应用艾地苯醌治疗的100例血管性痴呆患者设为对照组，运用艾地苯醌联合灯盏细辛治疗的100例血管性痴呆患者设为观察组。观察两组患者的治疗效果与不良反应发生情况。结果对照组治疗有效率为68．00％，不良反应率为11．00％。观察组有效率为86．00％，不良反应率为6．00％。观察组总有效率和不良反应率均好于对照组，差异有统计学意义（P〈0．05）。结论艾地苯醌联合灯盏细辛治疗血管性痴呆可显著提高治疗效果且不良反应率没有显著提升。此联合用药方法具有较高的安全性，各自发挥应有药效，起效快。值得临床推广使用。

Objective To investigate the efficacy and safety of idebenone and erigeron breviscapus in treatment of vasculardementia. Methods The clinical data of 200 cases of vascular dementia who were treated from January 1st 2012 to January 1st 2014 were analyzed. The 100 patients accepted ide- benone were set at control group and another 100 patients received combined use of idebenone and erigeron breviscapus were set as observation group. The treatment effect and adverse events were observed. Resuits The effective rate and adverse reactions rate of observaotion group were 68.00% and 11.00%, which was significantly lower than that of control group （ 86. 00% and 6.00% respectively, and P 〈 0. 05）. Conclusions Idebenone combined with erigeron breviscapus can significantly improve the therapeutic effect, without increasing the adverse reaction rate. This combination method is safe and effective,and is worthy of clinical use.