乙肝解毒方联合拉米夫定抗病毒治疗慢性乙型病毒性肝炎疗效观察

Clinical observation of the treatment of Yigan Jiedu Decoction and Lamivudine on Chronicity hepatitis-B

目的:观察乙肝解毒方联合拉米夫定对慢性乙型病毒性肝炎湿热中阻证型抗病毒治疗的影响。方法:选取中医辨证为湿热中阻证型的慢性乙型病毒性肝炎患者68例,随机分为西药组、联合组2组。分别给予口服拉米夫定、拉米夫定联合乙肝解毒方治疗,在24周内分时间段观察患者的血清丙氨酸氨基转移酶(ALT)、乙肝-DNA(HBV-DNA)定量等指标。结果:2组患者治疗后ALT,HBV-DNA均明显降低,治疗前后对比,差异均具统计学意义(P<0.05)。2组患者在治疗后24周时指标改善方面差异无统计学意义,但中药联合组在降低转氨酶、乙肝病毒HBV-DNA病毒载量方面,12周之前有明显的加强作用(P<0.01)。结论:乙肝解毒方联合拉米夫定抗病毒治疗湿热中阻证型的乙肝患者能起到更强的病毒抑制作用,且对患者的肝功能改善方面有着更好的疗效。但远期疗效接近,考虑治疗经济费用方面,建议在12周之前采取联合治疗方案。

Objective：To observe the Yigan Jiedu Decoction and Lamivudine（LAM） on treating the patients with Chronicity hepatitis-B.Methods：68 patients with Chronicity hepatitis-B were chosen and divided into two groups randomly, 34 cases in the treatment group were treated by Yigan Jiedu Decoction and LAM, and the other group of 34 cases were treated by LAM only, one treatment course was 24 weeks, observation of clinical symptoms,ALT,HBV-DANRCR changes were recorded before and after treatment.Results： There was no obvious difference of liver function between the control group the treatment group before the cure（P〉0.05）, significantly improvement of ALT and HBV-DNA-RCR was found in two groups after the cure（P〈0.05）, There was no obvious difference of between the treatment and the control group in 24 week（P〉0.05）, significantly improvement of liver founction,HBA-DNA was found in two groups in the early 12 weeks（P〈0.01）. Conc1usions： Yigan Jiedu Decoction and LAM can alleviate inflammation of the liver, used in the treatment of non- alcoholic fatty liver disease has good curative ef fect,and is more cheap in the early 12 weeks.