腹腔感染患者引流液病原菌分布与耐药性分析

Distribution and drug resistance of pathogens isolated from drainage fluid of patients with intra-abdominal infections

目的调查分析肝胆外科腹腔感染引流液的病原菌分布及耐药性,为临床治疗提供参考依据。方法选择2012年1月-2014年6月收治的100例肝胆外科腹腔感染患者为研究对象,总结病原菌分布及耐药性,采用SPSS17.0进行统计分析。结果 100例肝胆外科腹腔感染患者送检标本阳性80例,阳性率为80.0%;共检出106株病原菌,以革兰阴性菌为主,共62株占58.5%;革兰阴性菌对头孢呋辛、左氧氟沙星、四环素和克拉霉素的耐药率分别为61.3%、79.0%、64.5%和69.4%。结论肝胆外科腹腔感染引流液细菌学检验阳性率较高,病原菌主要为革兰阴性菌,临床抗感染治疗应结合药敏试验结果选择合用的抗菌药物。

OBJECTIVE To investigate the distribution and drug resistance of the pathogens isolated from the drainage fluid of the patients with intra-abdominal infections in department of hepatobiliary surgery so as to provide guidance for clinical treatment.METHODS A total of 100 patients with intra-abdominal infections who were treated in the department of hepatobiliary surgery from Jan 2012 to Jun 2014 were recruited as the study objects,then the distribution and drug resistance of the pathogens were observed,and the statistical analysis was performed with the use of SPSS17.0software.RESULTS The submitted specimens were cultured positive for 80 of 100patients with intra-abdominal infections,with the positive rate of 80.0%.Totally 106 strains of pathogens have been isolated,of which 58.5%（62strains）were the gram-negative bacteria.The drug resistance rates of the gramnegative bacteria to cefuroxime,levofloxacin,tetracycline,and clarithromycin were 61.3%,79.0%,64.5%,and69.4%,respectively.CONCLUSIONThe positive rate of the bacteriological test for the drainage fluid of the hepatobiliary surgery department patients with intra-abdominal infections is high.The gram-negative bacteria are the predominant pathogens.As for the clinical treatment of the infections,the antibiotics should be reasonably used based on the results of drug susceptibility testing.