血液病患者合并带状疱疹的临床特征与危险因素分析

Clinical characteristics and risk factors for herpes zoster in hematology ward

目的探讨血液病患者合并带状疱疹的临床特征及相关危险因素,以便采取措施减少血液病房患者带状疱疹的发生。方法选择2008年7月-2013年6月血液科6 118例住院患者,对其医院感染及发生带状疱疹的临床资料进行回顾性分析,通过单因素分析筛选发生带状疱疹的危险因素,并以多元logistic回归分析发生带状疱疹的高危因素,探讨控制措施,采用SPSS17.0软件进行统计分析。结果 6 118例血液病患者共发生医院感染1 109例,感染率18.1%,其中发生带状疱疹57例,发生率0.9%,发生率逐年升高;年龄≥60岁、化疗、合并糖尿病、疾病未缓解、粒细胞缺乏是血液病患者发生带状疱疹的危险因素,多因素分析显示,年龄≥60岁和化疗是血液病患者发生带状疱疹最主要的危险因素(P<0.05)。结论针对发生带状疱疹的危险因素,采取切实可行的措施,以减少血液病患者带状疱疹的发生。

OBJECTIVE To investigate the clinical characteristics and relevant risk factors of herpes zoster（HZ）in patients with hematological diseases so as to take countermeasures to reduce the incidence of HZ in hematology ward.METHODS A retrospective review of 6118 patients in hematology ward from Jul.2008 to Jun.2013 was performed.Clinical data of nosocomial infections and HZ in these patients were retrospectively reviewed.The single-factor analysis was used to screen risk factors of HZ and the multivariate logistic regression analysis to analyze high-risk factors.The control measures were discussed and the software SPSS17.0was used for statistical analysis.RESULTS Of 6118 cases of patients in hematology wards,nosocomial infections occurred in 1109cases（18.1%）,among which there were 57cases（0.9%）of HZ.The incidence rates of infections were increasing by years.Age over 60 years,chemotherapy,complication with diabetes,disease with no remission,and neutropenia were the risk factors leading to herpes zoster in hematological patients.The multivariate logistic regression analysis showed that age over 60 years and chemotherapy were the major risk factors（P〈0.05）.CONCLUSIONIt is necessary to take corresponding countermeasures targeting at risk factors to reduce the incidence of HZ in hematology wards.