慢性萎缩性胃炎患者的危险因素与临床治疗效果

Investigation of risk factors for chronic atrophic gastritis and comparative analysis of the clinical effects of different treatments for Hp patients

目的探讨发生慢性萎缩性胃炎患者危险因素,并对比不同方案治疗幽门螺杆菌阳性患者的临床效果,为临床诊治提供参考。方法选取2010年3月-2014年4月90例慢性萎缩性胃炎患者,列为萎缩组,选取同期94例慢性非萎缩性胃炎患者,列为非萎缩组,对比两组患者临床资料分析危险因素;将萎缩组50例Hp阳性患者随机分为观察组与对照组,每组各25例,进行不同治疗方案,对比分析两组患者治疗效果。结果年龄、胆汁反流、胃癌家族史、Hp感染是慢性萎缩性胃炎危险因素;慢性萎缩性胃炎患者中观察组治疗有效率92.00%、对照组为80.00%,两组对比差异有统计学意义(P<0.05)。结论高龄、家族胃癌史、胆汁反流是慢性萎缩性胃炎危险因素,以叶酸为主的联合治疗方案治疗慢性萎缩性胃炎患者Hp阳性效果好。

OBJECTIVE To investigate risk factors for chronic atrophic gastritis and to compare the clinical effects of different treatments for Hp patients,so as to provide a reference for clinical treatment.METHODS Totally 90 cases of patients with chronic atrophic gastritis were selected from Mar.2010 to Apr.2014.They were set as a atrophy group.During the same period,another 94 cases of patients with non-chronic atrophic gastritis were selected as non-atrophy group.The risk factors were analyzed according to the comparison of the clinical data of the two groups.The patients in the atrophic group with 50 Hp cases were randomly divided into observation group and control group with 25 cases each.Different treatments were used in two groups and the clinical effect of the two groups were compared.RESULTS The age,bile reflux,family history of gastric cancer,and Hp infections were risk factors for chronic atrophic gastritis.In observation group,the therapy efficiency rate was 92.00% and in the control group the treatment efficiency rate was 80.00%.The difference was significant（P〈0.05）.CONCLUSION Age,family history of gastric cancer and bile reflux are risk factors for chronic atrophic gastritis,and folic acid-based treatment has a good clinical effect for treating chronic atrophic gastritis.