原发性高血压中老年患者的综合降压方案研究

Study on comprehensive antihypertensive program in essential hypertension in elderly patients

目的研究原发性高血压中老年患者的综合降压方案。方法选取2012年1月—2013年2月来我院接受治疗的原发性高血压中老年患者78例,随机分为A、B两组,两组人数均为39例,A组采用氨氯地平+替米沙坦综合降压方案;B组采用氨氯地平+复方阿米洛利综合降压方案。对比两组患者的降压效果。结果用药6个、18个月后,相比A组,B组患者的收缩压、舒张压与心率并无显著差异;相比用药前,两组患者在用药6个、18个月后收缩压、舒张压均显著降低,差异具有统计学意义(P<0.05);相比用药前,两组患者在用药6个、18个月后心率均无显著变化。用药6个、18个月后,两组患者在降压显效率、总有效率方面并无显著差异。结论对于原发性高血压中老年患者,采用氨氯地平+替米沙坦或复方阿米洛利综合降压方案均具有显著的降压效果,且不会导致心率失常。

Objective To study the comprehensive antihypertensive program in essential hypertension in elderly pa- tients. Methods Selected 78 elderly patients with essential hypertension from January 2012 to February 2013 in our hospital, randomly dividing into A IB two groups, the number of two groups was 39 cases, the group A was treated with amlodipine ＋ telmisartan comprehensive antihypertensive program, the group B was treated with amlodipine ＋ compound amiloride comprehensive antihypertensive program. Compared the antihypertensive effect of the two groups. Results Af- ter 6 and 18 months, compared with group A, the patients in group B of systolic pressure, diastolic pressure and heart rate had no significant difference ; compared with before treatment, the patients in two groups of the systolic and diastolic pressure after 6 and 18 months were significantly reduced,with statistically significant difference（ P 〈 0. 05 ）, compared with before treatment,the heart rate of patients in the two groups had no significant change after 6 and 18 months. After 6 and 18 months treatment,the antihypertensive significant efficiency and total efficiency rate of two groups of patients had no significant difference. Conclusion For essential hypertension in elderly patients, using amlodipine ＋ telmisartan or compound amiloride comprehensive antihypertensive program has obvious antihypertensive effect, and does not lead to arrhythmia.