乙酰半胱氨酸治疗慢性阻塞肺疾病稳定期的观察

Clinical observation of acetylcysteine effervescent table on stable phase of chronic obstructive pulmonary disease

目的观察乙酰半胱氨酸泡腾片对慢性阻塞性肺疾病(COPD)稳定期的治疗效果。方法将COPD稳定期患者46例随机分为对照组和观察组,各23例,两组均给予平喘化痰药物等常规治疗;观察组在常规治疗基础上给予口服乙酰半胱氨酸泡腾片治疗。观察两组治疗前后FEV1、FEV1/FVC及6min步行距离和血清中白细胞介素-8(IL-8)、肿瘤坏死因子(TNF-a)含量的变化。结果治疗后观察组FEV1、FEV1/FVC改善,6min步行距离增加,血清中细胞因子IL-8和TNF-a含量降低,与对照组治疗后比较差异有统计学意义(P<0.05)。结论乙酰半胱氨酸泡腾片治疗慢性阻塞性肺疾病稳定期,能更好地改善患者的肺功能,降低患者体内的炎症水平,提高患者的生活质量。

Objective To evaluate the clinical effect of acetyleysteine effervescent table for the patients with stable phase of chronic obstructive pulmonary disease（COPD）. Methods Totally 46 patients with stable phase of COPD were allocated into two groups in random, the control group （ n = 23） received conventional theray, the treatment group （ n = 23 ） received acetylcysteine effervescent table on basis of conventional theray. The two groups were recorded the changes of pul- monary function, six min walking distance and IL - 8,TNF - a in blood serum before and after the treatment. Results After treatment, the pulmonary function and six rain walking distance in the treatment group were improved, the IL - 8, TNF -a in blood serum were lower than those in the control group. There are great difference between the two groups（P 〈0. 05）. Conclusion After therapy of acetylcysteine effervescent, pulmonary function and life quality of the patients with stable phase of chronic obstructive pulmonary disease can be effectively improved,the inflammation factor level was decreased.