第二代Grubbs催化剂配体的合成及优化

Synthesis and Optimization of the Second-generation Grubbs' Catalyst Ligand

Grubbs催化剂是一种用于烯烃复分解反应的配位化合物,其中的配体对于催化剂的催化性能、稳定性有很大的影响。目前,N-杂环卡宾(N-heterocyclic carbenes,NHC)是第二代Grubbs催化剂中的一个关键配体。本文以乙二醛为原料,通过取代、还原、环化等反应,合成了一种氮杂环卡宾的前驱体1,3-二取代-2-羧基咪唑啉。在此基础上,对部分关键合成环节进行了优化。研究结果表明,在乙二醛-双-(2,4,6三甲基苯基)亚胺的合成过程中,随着反应温度的升高,产率逐渐升高,后有所降低。在3-(2,4,6三甲基苯基)-2-羧基咪唑啉的合成过程中,反应时间对收率影响最大。

Grubbs catalyst is a coordination compound for olefin metathesis. The ligand in the Grubbs＂ catalyst has great influence on the function and stability of the catalyst. At present, N - heterocyclic carbene （NHC） is a key ligand for the second generation of Grubbs＇catalyst. In this paper, using glyoxal as raw materials, 1,3 - substituted - 2 - carboxy -imidazoline as pre -heterocyclic carbene was synthesized by substitution, reduction and cyclization re- actions. On this base. some key steps were optimized by reaction temperature and time.