益气活血消积方联合介入疗法治疗中晚期原发性肝癌疗效及安全性分析

Analysis of Efficacy and Safety of Yiqi Huoxue Xiaoji Recipe Combined with Interventional Therapy in Treating Middle-stage or Advanced Primary Hepatocarcinoma

目的:观察益气活血消积方剂联合介入治疗中晚期原发性肝癌临床疗效。方法:60例中晚期原发性肝癌,分为2组,各30例。对照组采用介入治疗;研究组在对照组治疗基础上联合益气活血消积方。观察3月。结果:总有效率研究组83.33%,对照组63.33%,2组比较,差异有统计学意义(P<0.01)。2组治疗后,基质金属蛋白酶-9(MMP-9)、甲胎球蛋白(AFP)、谷丙转氨酶(ALT)、谷草转氨酶(AST)比较,差异均有统计学意义(P<0.01)。肝功能损害率研究组6.67%,对照组16.67%,2组比较,差异有统计学意义(P<0.05);不良反应总发生率研究组16.67%,对照组33.33%,2组比较,差异有统计学意义(P<0.01)。结论:益气活血消积方剂联合介入治疗中晚期原发性肝癌临床疗效佳,可有效改善患者肝功能损害,降低不良反应发生率,促进病情的预后及转归。

Objective： To investigate the clinical efficacy of Yiqi Huoxue Xiaoji Recipe combined with interventional therapy in treating patients with middle-stage or advanced primary hepatocarcinoma. Methods： Sixty patients with middle-stage or advanced primary hepatocarcinoma were evenly divided into control group and research group. The control group received interventional treatment, and the research group was treated with Yiqi Huoxue Xiaoji Recipe on the basis of the treatment for the control group. Results： The total effective rate was 83.33% in the research group, and was 63.33% in the control group, the difference being significant （P 〈0.05）. Before treatment, the differences of levels of matrix metalloproteinases （MMPs） alpha-fetoprotein （AFP）, aminotransferase （ALT）, and aspartate aminotransferase （AST） was insignificant between the two groups （P〉 0.05）. After treatment, the differences of levels of the observation indexes between the two groups were significant {P〈 0.05）. The liver function damage rate was 6.67% and adverse reaction incidence was 16.67% in the research group, and was 16.67% and 33.33% respectively in the control group, the difference all being significant（P〈0.05）. Conclusion： Yiqi Huoxue Xiaoji Recipe combined with interventional therapy for middle-stage or advanced primary hepatocarcinoma delivers better efficacy by effectively relieving the damage of hepatic function, reducing the incidence of adverse reaction, and improving the prognosis and outcome of disease.