阿托伐他汀对急性冠脉综合征行PCI术后疗效及炎症因子的影响

Influence of atorvastatin on effect and inflammatory factors after percutaneous transluminal coronary intervention in patients with acute coronary syndrome

目的探讨两种常规剂量阿托伐他汀对急性冠脉综合征(ACS)行经皮冠状动脉介入术(PCI)患者的疗效及炎症因子的影响。方法行PCI术的ACS患者102例随机分为A组(阿托伐他汀钙10 mg)和B组(阿托伐他汀钙20 mg)。比较2组患者PCI手术前后血脂[总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)]和炎症因子[超敏C反应蛋白(hsCRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]水平,观察术后30、180 d的主要心脏不良事件发生情况。结果 PCI术后,2组TC、TG、LDL-C与术前比较,差异均有统计学意义(P<0.05)。2组术前、术后24 h血清TNF-α、IL-6、hs-CRP比较,差异均无统计学意义(P>0.05);术后7、30 d比较,差异均有统计学意义(P<0.05)。2组主要心脏不良事件发生率比较无显著差异(P>0.05)。结论两种剂量的阿托伐他汀治疗ACS患者行PCI均安全有效,均能明显降低术后炎症因子水平。

Objective To investigate the influence of two routine doses of atorvastatin on effect and inflammatory factors after percutaneous coronary intervention（ PCI） in patients with acute coronary syndrome（ ACS）. Methods A total of 102 ACS patients underwent PCI surgeries were randomly divided into group A（ 10 mg of atorvastatin calcium） and group B（ 20 mg of atorvastatin calcium）. Serum lipid[total cholesterol（ TC）,low density lipoprotein cholesterol（ LDL-C）,triglyceride（ TG） ]and inflammatory cytokines[high sensitivity C-reactive protein（ hs-CRP）,tumor necrosis factor（ TNF-α）,interleukin-6（ IL-6） ]levels were compared between two groups,and incidence of major adverse cardiac events were observed on the 30 th and 180 th day after operation. Results After PCI,there were significant differences in TC,LDL-C and TG when compared with preoperative period in both of the group A and the group B（ P 0. 05）. There were no significant differences in TNF-α,IL-6 and hs-CRP at the time points of before treatment and 24 hours after treatment in both groups（ P 0. 05）,but there were significant differences at the time points of the 7th day and 30 th day after operation between two groups（ P 0. 05）. There was no significant difference of incidence rate of major adverse cardiac events between two groups（ P 0. 05）. Conclusion Two doses of atorvastatin are safe and effective in the treatment of ACS patients with PCI,and it can significantly decrease the levels of inflammatory factors after PCI operation.