肝动脉化疗栓塞联合射频消融术治疗原发性肝癌的疗效分析

Efficacy of transcatheter arterial chemoembolization combined with radiofrequency ablation in the treatment of primary liver cancer

目的探讨肝动脉化疗栓塞(TACE)联合射频消融术(RFA)治疗原发性肝癌的临床疗效及安全性。方法根据意愿不同,将70例中晚期原发性肝细胞癌(HCC)患者分为TACE+RFA组37例和TACE组33例。TACE+RFA组采用TACE联合RFA治疗,TACE组采用TACE,观察2组血清甲胎蛋白(AFP)水平的变化,比较治疗3个月后的临床疗效及半年、1年、2年生存率,并记录并发症的发生情况。结果 TACE+RFA组血清AFP水平下降率明显大于TACE组(P<0.05),且总有效率显著高于TACE组(P<0.05)。TACE+RFA组1、2年生存率明显优于TACE组,差异均有统计学意义(P<0.05或P<0.01)。治疗期间,2组均未见严重并发症发生。结论 TACE联合RFA能有效治疗HCC,延长患者生存期,其疗效优于TACE单纯治疗。

Objective To explore the efficacy and safety of transcatheter arterial chemoembolization（ TACE） combined with radiofrequency ablation（ RFA） in the treatment of primary liver cancer. Methods According to different willing,70 patients with middle advanced primary hepatic cellular cancer（ HCC） were divided into TACE ＋ RFA group（ n = 37） and TACE group（ n = 33）. The TACE ＋ RFA group was treated with TACE combined with RFA,while the TACE group was only treated with TACE. The change of serum alpha fetoprotein（ AFP） level was observed. Clinical efficacy after 3 months of treatment was compared and survival rates in different time points of half a year,1 year and 2 years after treatment were compared,and the incidence of complications was recorded. Results Reduction rate of serum AFP level in the TACE ＋ RFA group was significantly greater than that in the TACE group,while the overall response rate was significantly higher than the TACE group（ P 0.05）. Survival rates in time points of 1 year and 2 years after treatment in the TACE ＋ RFA group were significantly better than those in the TACE group（ P 0. 05 or P 0. 01）. During treatment,no severe complications were observed in both groups. Conclusion TACE combined with RFA can effectively treat HCC and prolong the survival period of patients.