表皮生长因子用于痔术后创面治疗的效果

Clinical observation of recombinant human epidermal growth factor in wound healing after heamorrhoids surgery

目的通过表皮生长因子（EGF）溶液纱条和生理盐水纱条用于痔术后创面治疗（换药）,观察表皮生长因子用于痔术后创面治疗（换药）效果。方法研究资料来源于2011年1月至2014年1月期间中山大学孙逸仙纪念医院和广东省珠海市人民医院150例Ⅲ度痔术后患者。把符合病例诊断标准、入选病例标准和排除标准的150例Ⅲ度痔术后患者的创面随机分成2组,78例患者的创面使用表皮生长因子溶液纱条（实验组）,72例患者的创面使用生理盐水纱条换药（对照组）。期间不曾使用其他口服药物和外用药物,两组均以14天为观察期观察Ⅲ度痔术后患者的创面愈合情况。结果在14天为观察期观察Ⅲ度痔术后患者的创面愈合时,实验组总有效率为98.72%,对照组总有效率为90.28%（P〈0.001）。实验组创面愈合时间为12.6±3.16天（10-16天）,对照组为17.9±5.23天（12-23天）,两者差异有统计学意义（P〈0.05）。结论表皮生长因子溶液应用有助于痔术后创面愈合,减少创面的愈合时间。

Objective To observe the clinical effect of epidermal growth factor（EGF） wetwrap on wound healing after hemorrhoids surgery. Methods 150 patients with mixed hemorrhoids treated at Sun Yat-sen Memorial Hospital and People＇s Hospital of Zhuhai from January 2011 to January 2014 were recruited in this study. All the 150 patients were underwent hemorrhoids surgery and randomly divided into two groups. 78 patients（experimental group） were changed dressing using epidermal growth factor solution gauze and 72 patients（control group） received change dressing using saline gauze. No oral drugs and other topical drugs were used during the wound healing. Wound healing was divided into four grades included cured, markedly effective, effective and invalid. The wound healing was evaluated at the fourteen day after treatment. Results The total effective rate of the experimental group was 98.72%, and the control group was 90.28%. The statistical analysis showed that the total effective rate between the two groups was significance different（P 0.05）. The average healing time of the experimental group was 12.6 ±3.16 days（range from 11-16 days） and the control group was 17.9 ±5.23 days（range from 12-23 days）（P 0.05）. Conclusion EGF wet wrap can promote skin wound repair, shorten the wound healing time.