不同降压药物对痛风合并高血压患者代谢指标的干预价值

Intervention value of different antihypertensive drugs on metabolic indexes of gout patients with hypertension

目的探讨不同降压药物对于痛风合并高血压患者代谢指标的影响。方法 98例痛风合并高血压患者分为未用药组(n=11)、利尿剂组(n=16)、CCB组(n=22)、β受体阻滞剂组(n=20)、ARB组(n=15)以及ACEI组(n=14),比较各组治疗后代谢指标。结果治疗后,ARB组尿酸排泄分数(FEUA)显著提高,甘油三酯(TG)、尿素氮(BUN)、血清尿酸(SUA)及肌酐(Cr)显著降低(P<0.05);CCB组及ACEI组SUA、BUN、TG显著降低(P<0.05);利尿剂组和β受体阻滞剂组SUA显著升高(P<0.05)。结论不同降压药物对于痛风合并高血压患者的代谢指标存在不同程度的影响,应用ARB类药物可起到降低SUA及提高FEUA的作用,疗效较好。

Objective To investigate the influence of different antihypertensive drugs on metabolic indexes of gout patients with hypertension. Methods 98 cases of gout patients with hypertension were divided into untreated group（n = 11）, diuretic group（n = 16）, CCB group（n = 22）, β-blocker group（n = 20）, ARB group（n = 15） and ACEI group（n = 14）. The metabolic indexes of the groups after treatment were compared. Results After treatment,the FEUA of ARB group was significantly increased（P〈0.05）, and the SUA, BUN, TG and Cr were significantly decreased（P〈0.05）; The SUA, BUN,TG of CCB group and ACEI group were significantly decreased（P〈0.05）; the SUA of diuretics and β-blocker group were significantly increased（P〈0.05）. Conclusion Different antihypertensive drugs for gout patients with hypertension have varying degrees influence on metabolic index：ARB drugs can reduce the SUA and improve FEUA.