抗甲状腺药物治疗孕妇甲状腺功能亢进的疗效及对胎儿的影响

Efficacy of Anti-Thyroid Drugs in Treating Pregnant Women with Hyperthyroidism and Their Influence on Fetus

目的探讨抗甲状腺药物治疗孕妇甲状腺功能亢进的疗效及对胎儿的影响。方法将70例甲状腺功能亢进的孕妇按是否接受抗甲状腺药物治疗分为研究组和对照组,各35例。研究组孕妇给予抗甲状腺药物治疗,对照组孕妇未接受抗甲状腺药物治疗。观察并比较两组患者的疗效及胎儿的发育情况。结果研究组孕妇足月顺产30例,早产5例,对照组孕妇流产或死胎15例,足月顺产15例,早产5例;两组新生儿在性别、胎龄、出生体重等方面比较,差异均无统计学意义(P>0.05);研究组患者总有效率为77.14%,显著高于对照组的28.57%(P<0.05);研究组和对照组新生儿游离T3(FT3)、游离T4(FT4)、血清总T4(TT4)水平无显著性差异(P>0.05)。结论抗甲状腺药物治疗孕妇甲状腺功能亢进可显著促进孕妇的健康,且对胎儿无明显不良反应。

Objective To investigate the efficacy of anti- thyroid drugs in treating pregnant women with hyperthyroidism and their influ- ence on fetus. Methods Totally 70 pregnant women with hyperthyroidism were divided into the study group and the control group ac- cording to whether or not accepting the antithyroid drug therapy,35 cases in each group. The pregnant women in the study group were given the anti- thyroid drugs,while the pregnant women in the control group were not given the anti- thyroid drugs. The efficacy and the influence on the fetal development were observed and compared between the two groups. Results The study group had 30 cases of full-term normal delivery,5 cases of premature labor;while the control group had 15 cases of miscarriage or stillbirth,and 15 cases of full- term normal delivery and 5 cases of preterm labor. The neonates in the two groups had no statistically significance differences in the aspects of gender, gestational age,birth weight and so on（P 〉 0. 05）.The total effective rate in the study group was 77.14%, which was significantly higher than 28.57% in the control group（ P 〈 0. 05）. The FF3, FF4 and T]＇4 levels had no statistically signifi- cant difference between the study group and the control group（ P 〉 0. 05）. Conclusion Anti- thyroid drugs can significantly promote the health of pregnant women with hyperthyroidism and has no obvious adverse reactions on fetus.