灯盏花素治疗膝关节骨性关节炎45例

Breviscapine for Treating Knee Osteoarthritis in 45 Cases

目的观察灯盏花素治疗膝关节骨性关节炎的临床疗效。方法选取医院2012年1月至2013年3月收治的膝关节骨性关节炎患者90例,按入院先后顺序随机分为两组,各45例。两组患者均采用关节腔给药疗法,观察组患者采用灯盏花素注射液,对照组患者采用玻璃酸钠注射液。比较两组患者治疗前后Lysholm膝关节的功能评分、视觉模拟评分法(VAS)评分,并评价疗效。结果观察组总有效率为95.56%,明显高于对照组的77.78%(χ2=5.47,P<0.05);两组患者治疗后Lysholm评分均显著升高(P<0.05),VAS评分均显著降低(P<0.05),组间比较,差异均有统计学意义(P<0.05);两组患者均未见明显的全身不良反应,且均未发生感染。结论灯盏花素关节腔给药治疗膝关节骨性关节炎更能缓解疼痛,改善关节功能,且不良反应少,值得临床推广。

Objective To investigate the clinical effect of breviscapine in treating knee osteoarthritis. Methods Totally 90 cases of knee osteoarthritis admitted to the hospital from January 2012 to March 2013 were selected and randomly divided into two groups according to the admission sequence,45 cases in each group. The two groups were all treated with the intra-articular injection therapy. The ob-servation group used Breviscapine Injection,while the control group was given Sodium Hyaluronate Injection. The Lysholm knee function scores and the VAS scores before and after treatment were compared between the two groups and the clinical efficacy was evaluated. Results The total effective rate of the observation group was 95. 56%,which was significanty higher than 77. 78% in the control group（χ2=5. 47,P 〈 0. 05）. The Lysholm scores after treatment in the two groups were increased significantly（ P 〈 0. 05） and the VAS scores were decreased significantly（ P 〈 0. 05）. Comparison between the two groups showed statistical difference（ P 〈 0. 05）. There was no obvious systemic adverse reactions in the two groups,moreover no infection occurred. Conclusion Breviscapine by intra-articular injection in treating osteoarthritis can relieve pain,improve the joint function,has fewer adverse reactions,and is worthy of clinical promotion.