胰岛素样生长因子结合蛋白-1用于检测胎膜早破的临床诊断意义分析

Insulin-like growth factor binding protein 1 premature rupture of membranes used to test analysis of the clinical diagnostic significance

目的探讨胰岛素样生长因子结合蛋白-1(IGFBP-1)在检测胎膜早破中的临床诊断意义。方法病例来源于我院2010年2月至2014年3月确诊为胎膜早破孕妇390例,据孕妇临床症状与检查分为3组:A组为胎膜未破者135例,B组为胎膜怀疑可能破裂者145例,C组为胎膜已破者110例。采集每例孕妇的阴道分泌物,运用阴道分泌物涂片、pH试纸、IGFBP-1 3种检测方法对其进行测试,对比分析3种方法的阳性预测值、阴性预测值、特异性、灵敏度。结果对孕妇胎膜早破的检测:IGFBP-1法阴性预测值91.61%,阳性预测值98.38%,灵敏度95.29%,特异性97.04%,明显高于pH试纸的64.04%、83.13%、79.22%、69.63%,也明显高于阴道分泌物涂片的66.44%、85.06%、80.39%、73.33%,差异均有统计学意义(P<0.05)。结论 IGFBP-1用于检测胎膜早破比阴道液涂片检测和pH试纸检测的灵敏性与准确性更高,其临床诊断价值更优越,值得在临床诊断中积极推广与应用。

Objective To investigate the insulin-like growth factor binding protein I（IGFBP-1）of premature rupture of membranes used to detect the clinical diagnostic significance. Methods From February 2010 to March 2010 diagnosed with premature rupture of membranes, Three hundred ninty cases of pregnant women, pregnant women who, according to clinical symptoms and examination is divided into three groups.. A, B, C group. Group A did not rupture of membranes for 135 cases, group B suspected may rupture of membranes for 145 cases, group C has broken for 110 cases. Collection each pregnant woman vaginal secretions, its using vaginal fluid smear, pH test paper, IGFBP-1 three detection methods for testing, analysis of three methods of positive predictive value, negative predictive value, specificity and sensitivity. Results Premature rupture of membranes of pregnant women testing： IGFBP-1 method, negative predictive value was 91.61%, positive predictive value was 98.38 %, the sen- sitivity was 95.29%, specificity of 97.04~, significantly higher than the pH test paper of 64.04%, 83.13%, 79.22%, 69.63%, and significantly higher than vaginal fluid smears of 66.44%, 85.06M, 80. 390//00, 73.33%, the differences were statistically significant （ P 〈0.05）. Conclusion Premature rupture of membranes used to de- tect IGFBP-1 than vaginal fluid smear tests and pH test paper detection sensitivity and accuracy is higher, its clini- cal diagnostic value is superior, is worth in the clinical diagnosis of positive popularization and application.