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鞘内孤啡肽对大鼠心血管活性的影响 被引量：1

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摘要 孤啡肽（N/OFQ）是1995年发现的一条含有17个氨基酸的阿片肽,它是阿片受体样受体ORL1或LC132受体的内源性配体[1,2]。N/OFQ系统主要分布于中枢神经系统,在外周如血管壁、肾上腺、肝脏、小肠、输精管、卵巢、脾、外周白细胞等均有分布,N/OFQ及其受体组成了一个新的肽受体系统,这一系统调节许多中枢及外周的功能：在脑水平上,N/OFQ刺激进食、产生抗焦虑效果、
作者 阴新强 敬媛媛
机构地区 川北医学院基础医学院分析中心 川北医学院基础医学院预防医学系
出处 《山西医药杂志》 CAS 2015年第7期759-760,共2页 Shanxi Medical Journal
基金 四川省教育厅资助项目(14ZB0204)
关键词 孤啡肽 心血管活性 大鼠 外周白细胞 中枢神经系统 阿片受体 内源性配体 调节运动 阿片肽 抗焦虑
分类号 R965 [医药卫生—药理学]
  • 相关文献

参考文献11

  • 1Meunier JC, Mollereau C, Toll L, et al. Isolation and struc- ture of the endogenous agonist of opioid receptor[J~. Nature, 1995, 377(6549):532-535.
  • 2Rernscheid RK, Nothacker HP, Bourson A, et al. Orphanin FQ:a neuropeptide that activaties an opioidlike G protein- coupled receptor[J]. Science, 1995, 270(5237) : 792-794.
  • 3Bodnar RJ. Endogenous opiates and behavior: 2013[J]. Pep- tides, 2014, 9,62C:67-136.
  • 4Bodnar RJ. Endogenous opiates and behavior: 2012[J]. Pep tides, 2013,12,50 : 55-95.
  • 5Armstead WM. Nociceptin/orphanin phenylalanine gluta- mine (FQ) receptor and cardiovascular disease[J]. Cardio- vasc Ther,2011,29(1) ..23-28.
  • 6Doggrell SA. , Cardiovascular and renal effects of nociceptin/ orphanin FQ.. a new mediator to target? [J~. Curr Opin In- vestig Drugs, 2007,8(9) : 742-749.
  • 7晏庭林,李琳,刘新社.阿片受体及阿片肽研究进展[J].中国药物依赖性杂志,2009,18(5):375-379. 被引量：20
  • 8Madeddu P, Salis MB, Milia AF. Cardiovascular effect of noeiceptin in unanesthetized miceEJ~. Hypertension, 1999,33 (3) :914-919.
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二级参考文献39

  • 1唐勇,郝亮,罗群英,蒲艺,余曙光.孤啡肽的生物学功能研究进展[J].四川生理科学杂志,2000,22(2):13-15. 被引量：1
  • 2洪新如.下丘脑室旁核β-内啡肽在大鼠烫伤休克中的作用及其受体机制的研究[J].生理科学进展,1993,24(3):242-244. 被引量：10
  • 3纪家涛,王新华,由振东,韩同钦.吗啡依赖大鼠模型的建立[J].第二军医大学学报,1997,18(1):81-82. 被引量：90
  • 4Jenck F, Moreau JL, Martin JR, et al. Orphanin FQ acts as an anxiolytic to attenuate behavioral responses to stress[J]. Proc Natl Acad Sci USA, 1997, 94(26) : 14854- 14858.
  • 5Polidori C, Caro G, Massi M. The hyperphagic effect of nociceptin/orphanin FQ in rats[J]. Pepfides, 2000, 21(7) : 1051 - 1062.
  • 6Olszewski PK, Grace MK, Sanders JB, et al. Effect of nociceptin/orphanin FQ on food intake in rats that differ in diet preference[J]. Pharmacol Biochem Behav, 2002, 73(3) : 529 -535.
  • 7Wang XM, Zhang KM, Mokha SS. Nociceptin( orphanin FQ), an endogenous ligand for the QRL1 (opioid - receptor - llkel) receptor, modulates responses of trigeminal neurons evoked by excitatory amino acids and somatoseusory stimuli [ J ]. J Neurophysiol, 1996, 76 : 3568 - 3572.
  • 8Zadina JE, Hackler L, Ge LJ, et al. A potent and selective endogenous agonist for the mu - opiate receptor[ J ]. Nature, 1997, 386(6624) : 499 -501.
  • 9Dun N J, Dun SL, Hwang LL. Nociceptin - like immunore - activity in autonomic nuclei of the rat spinal cord [ J ]. Neurosci Lett, 1997, 234(23) : 95 -98.
  • 10Chen Y, Mestek A, Liu J, et al. Molecular cloning and functional expression of a μ - opioid receptor from rat brain [ J ]. Mol Pharmacol, 1993, 44:8.

共引文献19

同被引文献25

  • 1Meunier JC, Mollereau C, Toll L, et al. Isolation and structure of the endogenous agonist of opioid receptor. Nature, 1995, 377:532-535.
  • 2Reinscheid RK, Nothacker HP, Bourson A, et al. Orphanin FQ: a neuropeptide that activaties an opioid-like G protein-coupled receptor. Science, 1995, 270:792-794.
  • 3Bodnar RJ. Endogenous opiates and behavior: 2013.Peptides, 2014, 9, 62C: 67-136.
  • 4Bodnar RJ. Endogenous opiates and behavior: 2012. Peptides, 2013, 12, 50:55-95.
  • 5Armstead WM. Nociceptin/orphanin FQ phenylalanine glutamine receptor and cardiovascular disease. Cardiovase Ther, 2011, 29:23-28.
  • 6Doggrell SA. Cardiovascular and renal effects of nociceptin/orphanin FQ: a new mediator to target? Curr Opin Investig Drugs, 2007, 8:742-749.
  • 7Kuzmin A, Sandin J, Terenius L, et al. Evidence in locomotion test for the functional heterogeneity of ORL-1 receptors. Br J Pharmacol, 2004, 141:132-140.
  • 8Andero R. Nociceptin and the nociceptin receptor in learning and memory. Prog Neurpsy-chopharmacol Biol Psychiatry, 2015, 62:45-50.
  • 9Abdel-Mouttalib O. Nociceptin/orphanin-FQ modulation of learning and memory. Vitam Horm, 2015, 97:323-345.
  • 10Witkin JM, Statnick MA, Rorick-Kehn LM, et al. The biology of Nociceptin/Orphanin FQ(N/OFQ)related to obesity, stress, anxiety, mood, and drug dependence. Pharmacol Ther, 2014, 141:283-299.

引证文献1

山西医药杂志
2015年 第7期

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