血浆同型半胱氨酸水平对老年高血压患者轻度认知功能障碍的预测价值

The Predictive Value of the Plasma Homocysteine Level for the Mild Cognitive Impairment in Old Patients with Hypertension

目的探讨血浆同型半胱氨酸水平对老年高血压患者发生轻度认知功能障碍的预测价值。方法入选符合标准的老年高血压合并轻度认知功能障碍患者104例,并选取同期认知功能正常的老年高血压患者102例作为对照组,分析各组患者血浆同型半胱氨酸水平,并通过Logistic回归分析明确老年高血压患者发生轻度认知功能障碍的相关因素。结果老年高血压合并轻度认知功能障碍组与单纯高血压组的临床资料比较,在血浆同型半胱氨酸水平及高密度脂蛋白胆固醇水平上差异有统计学意义（t=4.251,P=0.006;t=3.302,P=0.015）;高同型半胱氨酸者轻度认知功能障碍的发病率明显升高（P〈0.05）;经Logistic回归分析显示高同型半胱氨酸血症是老年高血压患者发生轻度认知功能障碍的独立危险因素（OR=2.32,95%CI=1.31~4.16）,P〈0.05。结论高同型半胱氨酸血症对老年高血压患者发生轻度认知功能障碍具有预测价值。

Objective Investigate the predictive value of the plasma homocysteine level for the mild cognitive impairment in old patients with hypertension.Methods Selected 104 cases of old patients who met the standards and had mild cognitive impairment and hypertension,then selected 102 cases of homochronous old patients with hypertension who had normal cognition as control group,and analyzed each patient’s plasma homocysteine level.Made sure the correlative factor of the mild cognitive impairment in old patients with hypertension through Logistic regression analysis.ResultsCompared the group of old patients with hypertension and mild cognitive impairment with the group of old patients with only hypertension,their differences in the homocysteine level and the high density lipoprotein cholesterol level of the plasma were statistically significant（t=4.302,P=0.006;t=3.302,P=0.015）;The morbidity of the mild cognitive impairment in patients with high homocysteine was significantly increased（P〈0.05）;The Logistic regression analysis showed that the hyperhomocysteinemia was the independent risk factor of mild cognitive impairment in old patients with high homocysteine（OR=2.32,95% CI=1.31~4.16）,P〈0.05.Conclusion Hyperhomocysteinemia has predictive value for mild cognitive impairment in old patients with hypertension.