SALL4在肺腺癌组织中的表达及其意义

Expression and Significance of SALL4 in Lung Adenocarcinoma Tissues and Adjacent Tissue

目的研究SALL4基因在人肺腺癌组织中的表达及其意义。方法采用免疫组化法检测48例人肺癌组织及其癌旁组织SALL4表达,分析SALL4表达与临床病理特征之间的关系。结果 SALL4在肺腺癌组织的表达明显高于癌旁组织(37.5%比10.4%,P=0.002)。SALL4的表达与区域淋巴结转移、细胞分化程度密切相关(P=0.006,P=0.013),与性别、年龄及T分期无关(P>0.05)。结论 SALL4表达明显与肺腺癌相关,可能在肺腺癌的发生发展中发挥作用。

Objective To investigate the expression and significance of SALL4 gene in lung adenocarcinoma tissues.Methods We examined the expression of SALL4 in 48 lung adenocarcinoma tissues and paracancerous tissues using immunohistochemical method and analysed the relationship between the expression of SALL4 and clinical pathological features.Results The expression rate of SALL4 in lung adenocarcinoma tissues was significantly higher in paracancerous tissues（37.5% vs 10.4%,P=0.002）.The expression of SALL4 was strongly correlated with regional lymphatic metastasis and cell differentiation（P=0.006,P=0.013）,not related with sex,age,and T-periodization（P〉0.05）.ConclusionsSALL4 may contribute to the development of lung adenocarcinoma.