摘要
尽管有它的狭窄的治疗学的索引和毒性， BackgroundDigoxin 遗体今天广泛地使用了。学习是调查异羟基洋地黄毒苷的不恰当的使用和老病人的长期的结果的百分比的这的目的就医了因为异羟基洋地黄毒苷 toxicity.MethodsThe 学习包括了为异羟基洋地黄毒苷毒性就医的 99 个连续病人。如果参加者压抑左室的收缩功能，为异羟基洋地黄毒苷的不恰当的使用的另外的学习标准被考虑(喷射部分 <；45%) 不在包括贝它块和 angiotensin-converting-enzyme 禁止者治疗的最佳的医药治疗上或如果参加者有永久 AF 尽管有它的狭窄的治疗学的索引，不在最佳的贝它块 therapy.ResultsAppropriate 异羟基洋地黄毒苷用法上的人，在 33 个病人被证实。99 个病人中的 16 个的一个总数死了，与 22.1 ± 的一吝啬的后续时间；10.3 months.ConclusionsContrary 到流行信仰，不恰当的异羟基洋地黄毒苷用法的率仍然保持高。由于它的狭窄的治疗学的索引和毒性，异羟基洋地黄毒苷应该根据当前的证据和指南更小心地被使用。
Background Digoxin remains widely used today despite its narrow therapeutic index and toxicity. The objective of this study was to investigate the percentage of inappropriate use of digoxin and long-term outcomes of elderly patients hospitalized for digoxin toxicity. Methods The study included 99 consecutive patients hospitalized for digoxin toxicity. The other study criteria for the inappropriate use of digoxin was regarded if participants having depressed left ventricular systolic function （ejection fraction 〈 45%） who were not on optimal medical therapy including beta-blocker and angiotensin-converting-enzyme inhibitor therapy or if participants having permanent AF who were not on optimal beta-blocker therapy. Results Appropriate digoxin usage was confirmed in 33 of patients in spite of its narrow therapeutic index. A total of 16 of 99 patients died, with a mean follow-up time of 22.1 ± 10.3 months. Conclusions Contrary to popular belief, the rate of inappropriate digoxin usage remains high. On account of its narrow therapeutic index and toxicity, digoxin should be used more carefully according to the current evidence and guidelines.
