S-100β蛋白、NSE在重症和危重症手足口病患儿中的变化及临床意义

Changes and Clinical Significance of S-100 Protein, NSE in Severe and Critical HFMD in Children

目的:通过检测分析不同组别手足口病患儿血清及部分重症、危重症组脑脊液S-100β蛋白、神经元特异性烯醇化酶(NSE)数值的变化,探讨S-100β蛋白、NSE在手足口病诊断、治疗中的价值。方法:将550例手足口病患儿根据临床表现分为轻症、重症、危重症,分别于入院24小时内留取患儿的血清及部分重症、危重症患儿的脑脊液,检测S-100β蛋白、NSE的数值。结果:入院时诊断轻症,测得血清及脑脊液S-100β蛋白数值高于均值的患儿转为重症、危重症患儿的例数高于低于均值患儿的例数;入院时诊断重症,测得血清及脑脊液S-100β蛋白数值高于均值的患儿转为危重症患儿的例数高于低于均值患儿的例数,经统计学处理有显著差异;而脑脊液结果与血清对比无显著差异。结论:S-100β蛋白具有危重症早期识别的临床价值;检测血清S-100β蛋白在早期识别重症、危重症患儿的临床意义与检测脑脊液S-100β蛋白的意义相同。

Objective：Through the analysis of mild, severe,critical HFMD children serum and cerebrospinal fluid in children with severe,severe S-100 β protein,neuron specific enolase（NSE） numerical changes,Discussion of S-100βprotein,NSE in hand-footmouth disease diagnosis,therapeutic value.Methods：550 cases of hand foot and mouth disease according to the clinical manifestation is divided into mild,severe,critical illness,cerebrospinal fluid were taken within 24 hours of admission in children with severe,serum and part of critically ill children with numerical detection,S-100β protein,NSE.Results：Diagnosis of mild admission,measured in serum and cerebrospinal fluid of S-100 βprotein value higher than the mean children into several cases of severe,the number of cases of critically ill children is higher than that of below average children;diagnosis of severe admission,measured in cerebrospinal fluid and serum S-100 βprotein value is higher than the mean of the children to the number of cases of critically ill children was higher than that of the number of cases of children with lower than average,statistically significant difference;there was no significant difference between the results in serum and cerebrospinal fluid.Conclusion：S-100 βprotein has clinical value in the early identification of critical illness;detection of serum S-100 βprotein in the early recognition of severe,critically ill children with clinical significance and detection of cerebrospinal fluid S-100 βprotein the same meaning.